A Case of Immunoglobulin G4-Related Gastrointestinal Disease Diagnosed From Persistent Diarrhea and Abdominal Pain.

由持续性腹泻和腹痛诊断的免疫球蛋白 G4 相关胃肠道疾病一例。

• 发表时间: 2023
• 来源期刊: Gastro Hep Adv
• DOI: 10.1016/j.gastha.2023.07.009
• PMID: 39131561
• 文章类型: Case Reports
• 作者列表: Hirano T,Kawakami Y,Nakabayashi S,Wagatsuma K,Ishigami K,Masaki Y,Murota A,Kanda M,Sugita S,Notohara K,Nakase H

关键词: Abdominal Pain; Diarrhea; IgG4-Related Dacryoadenitis and Sialadenitis; IgG4-Related Disease; IgG4-Related Gastrointestinal Disease; Inflammatory Disease

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disease characterized by the infiltration of IgG4-positive plasma cells and fibrosis in organs throughout the body. IgG4-RD involvement in the gastrointestinal (GI) tract (IgG4-related GI disease; IgG4-GID) is rare, and the disease concept remains unclear. Generally, IgG4-GID has been reported with morphological changes, including ulcers, strictures, and submucosal tumors. Here, we report a case of IgG4-GID with persistent diarrhea and abdominal pain in which typical endoscopic findings were absent. This case suggests the unidentified clinical features of IgG4-GID.

摘要

免疫球蛋白G4相关疾病（IgG4-RD）是一种全身性炎症性疾病，其特征是IgG4阳性浆细胞浸润和全身器官纤维化。IgG4-RD在胃肠道（GI）受累（IgG4相关GI疾病；IgG4-GID）是罕见的，和疾病的概念仍不清楚。一般来说,据报道，IgG4-GID有形态学变化，包括溃疡,狭窄,粘膜下肿瘤.这里,我们报告了一例IgG4-GID伴持续性腹泻和腹痛的病例,其中不存在典型的内镜检查结果.该病例提示IgG4-GID的临床特征不明。