PDF(Pubmed)
Abstract：
Lumbar interbody fusion (LIF) is a surgical procedure for treating lumbar spinal stenosis and deformities. It removes a spinal disc and insert a cage or bone graft to promote solid fusion. Extensive research on LIF has been supported by numerous animal studies, which are being developed to enhance fusion rates and reduce the complications associated with the procedure. In particular, the anterior approach is significant in LIF research and regenerative medicine studies concerning intervertebral discs, as it utilizes the disc and the entire vertebral body. Several animal models have been used for anterior LIF (ALIF), each with distinct characteristics. However, a comprehensive review of ALIF models in different animals is currently lacking. Medium-sized and large animals, such as dogs and sheep, have been employed as ALIF models because of their suitable spine size for surgery. Conversely, small animals, such as rats, are rarely employed as ALIF models because of anatomical challenges. However, recent advancements in surgical implants and techniques have gradually allowed rats in ALIF models. Ambitious studies utilizing small animal ALIF models will soon be conducted. This review aims to review the advantages and disadvantages of various animal models, commonly used approaches, and bone fusion rate, to provide valuable insights to researchers studying the spine.
摘要：
腰椎椎间融合术（LIF）是一种治疗腰椎管狭窄和畸形的手术方法。它移除椎间盘并插入笼子或植骨以促进固体融合。对LIF的广泛研究得到了许多动物研究的支持，正在开发用于提高融合率并减少与手术相关的并发症。特别是,前路在LIF研究和有关椎间盘的再生医学研究中具有重要意义，因为它利用了椎间盘和整个椎体。几种动物模型已用于前LIF（ALIF），每个都有不同的特点。然而,目前缺乏对不同动物的ALIF模型的全面审查。中型和大型动物，比如狗和羊，已被用作ALIF模型，因为它们适合手术的脊柱尺寸。相反，小动物,比如老鼠,由于解剖学上的挑战，很少被用作ALIF模型。然而,外科植入物和技术的最新进展逐渐允许大鼠进入ALIF模型。利用小动物ALIF模型的雄心勃勃的研究将很快进行。这篇综述旨在回顾各种动物模型的优缺点,常用的方法，和骨融合率，为研究脊柱的研究人员提供有价值的见解。
