PDF(Pubmed)
Abstract：
UNASSIGNED: Sleep complaints were reported to be associated with stroke, however, the evidence on the association between healthy sleep pattern and stroke risk in Chinese is limited.
UNASSIGNED: The aim of this study was to investigate the association between healthy sleep pattern and stroke in Chinese, and the influence of metabolic diseases on the association.
UNASSIGNED: A total of 11,851 participants from the Kailuan study in China without stroke at baseline were included. We calculated a healthy sleep score according to four sleep factors, and defined the low-risk groups as follows: no insomnia, no excessive daytime sleepiness, no frequent snoring, and sleep 7-8h/d. Each low-risk sleep factor was assigned a score of 1. Cox proportional hazard models were used to assess the association between healthy sleep score and stroke. Mediation analysis was used to estimate the role of metabolic diseases (obesity, diabetes, and hypertension) in the healthy sleep score-stroke association.
UNASSIGNED: During a mean follow-up period of 7.7 years, 504 cases of stroke were identified. A higher healthy sleep score was associated with a lower risk of stroke in a dose-response manner (P-trend=0.03). The adjusted hazard ratio (HR) for participants with a healthy sleep score of 4 versus ≤2 was 0.75 (95% confidence interval [CI]: 0.56, 0.96). In addition, obesity, diabetes, and hypertension collectively explained 21.9% (95% CI: 17.2, 26.5) of the association between healthy sleep score and stroke.
UNASSIGNED: Adherence to healthy sleep pattern was associated with a lower risk of stroke, and the favorable association was partially mediated by metabolic diseases.
UNASSIGNED: The aim of this study was to investigate the association between healthy sleep pattern and stroke in Chinese, and the influence of metabolic diseases on the association.
UNASSIGNED: A total of 11,851 participants from the Kailuan study in China without stroke at baseline were included. We calculated a healthy sleep score according to four sleep factors, and defined the low-risk groups as follows: no insomnia, no excessive daytime sleepiness, no frequent snoring, and sleep 7-8h/d. Each low-risk sleep factor was assigned a score of 1. Cox proportional hazard models were used to assess the association between healthy sleep score and stroke. Mediation analysis was used to estimate the role of metabolic diseases (obesity, diabetes, and hypertension) in the healthy sleep score-stroke association.
UNASSIGNED: During a mean follow-up period of 7.7 years, 504 cases of stroke were identified. A higher healthy sleep score was associated with a lower risk of stroke in a dose-response manner (P-trend=0.03). The adjusted hazard ratio (HR) for participants with a healthy sleep score of 4 versus ≤2 was 0.75 (95% confidence interval [CI]: 0.56, 0.96). In addition, obesity, diabetes, and hypertension collectively explained 21.9% (95% CI: 17.2, 26.5) of the association between healthy sleep score and stroke.
UNASSIGNED: Adherence to healthy sleep pattern was associated with a lower risk of stroke, and the favorable association was partially mediated by metabolic diseases.
摘要：
■据报道，睡眠投诉与中风有关，然而,中国人健康睡眠模式与卒中风险相关的证据有限.
■这项研究的目的是调查健康睡眠模式与中国人中风之间的关系，以及代谢性疾病对关联的影响。
■共有11,851名来自中国开luan研究的基线无卒中参与者被纳入。我们根据四个睡眠因素计算出健康睡眠评分，并将低风险人群定义为：没有失眠，没有过度的白天嗜睡，没有经常打鼾,和睡眠7-8h/d。每个低危睡眠因子的评分为1分。Cox比例风险模型用于评估健康睡眠评分与卒中之间的关联。中介分析用于估计代谢性疾病(肥胖，糖尿病,和高血压）在健康睡眠评分-中风关联中。
■在平均7.7年的随访期内，确定了504例中风。较高的健康睡眠评分以剂量反应方式与较低的中风风险相关（P趋势=0.03）。健康睡眠评分为4与≤2的参与者的校正风险比（HR）为0.75（95％置信区间[CI]：0.56，0.96）。此外,肥胖，糖尿病,和高血压共同解释了21.9%(95%CI:17.2,26.5)的健康睡眠评分与卒中之间的关联.
■坚持健康的睡眠模式与较低的中风风险相关，有利的关联部分由代谢性疾病介导。
■这项研究的目的是调查健康睡眠模式与中国人中风之间的关系，以及代谢性疾病对关联的影响。
■共有11,851名来自中国开luan研究的基线无卒中参与者被纳入。我们根据四个睡眠因素计算出健康睡眠评分，并将低风险人群定义为：没有失眠，没有过度的白天嗜睡，没有经常打鼾,和睡眠7-8h/d。每个低危睡眠因子的评分为1分。Cox比例风险模型用于评估健康睡眠评分与卒中之间的关联。中介分析用于估计代谢性疾病(肥胖，糖尿病,和高血压）在健康睡眠评分-中风关联中。
■在平均7.7年的随访期内，确定了504例中风。较高的健康睡眠评分以剂量反应方式与较低的中风风险相关（P趋势=0.03）。健康睡眠评分为4与≤2的参与者的校正风险比（HR）为0.75（95％置信区间[CI]：0.56，0.96）。此外,肥胖，糖尿病,和高血压共同解释了21.9%(95%CI:17.2,26.5)的健康睡眠评分与卒中之间的关联.
■坚持健康的睡眠模式与较低的中风风险相关，有利的关联部分由代谢性疾病介导。
