PDF(Pubmed)
Abstract：
UNASSIGNED: Cholangiocarcinoma is a relatively rare malignancy with high mortality. In the U.S., incidence rates of cholangiocarcinoma have increased, particularly affecting younger age groups and Hispanic and Asian individuals. We investigated the incidence of cholangiocarcinoma in a largely under-represented, minority population.
UNASSIGNED: We performed a retrospective cohort study from 2005 to 2017 among adults in a county-funded healthcare system in Harris County, Texas. Incidence rate ratios were computed to compare age-standardized rates using U.S. standard population between 2 time periods: 2005-2011 and 2012-2017.
UNASSIGNED: We identified 139 cholangiocarcinoma cases (64% intrahepatic, 36% extrahepatic). The median age at diagnosis was 57 years; 62% were Hispanic, and 56% were born outside the U.S. The incidence rate increased from 1.2 to 2.4 per 100,000 person-years (rate ratio 2.1 [95% confidence interval {CI}: 1.5, 3.0]). Hispanic individuals and those aged 40-69 years had the highest rate of incidence increase (respectively, rate ratio: 2.5 [95% CI: 1.6, 4.0] and rate ratio: 2.0 [95% CI: 1.2, 3.0]) between time periods. In 2012-2017, the risk of cholangiocarcinoma among patients with diabetes was 1.4 times relative to those without (relative risk: 1.4; 95% CI: 1.1, 1.5) and 1.2 times among those who were overweight/obese relative to those who were not (relative risk: 1.2; 95% CI: 1.1, 1.6).
UNASSIGNED: Incidence of cholangiocarcinoma doubled during the 12-year study period, with Hispanic and middle-aged individuals disproportionately affected. Individuals with diabetes mellitus and those who were overweight or obese had a high risk of being diagnosed with cholangiocarcinoma in the later time period. Further studies should focus on preventing and improving earlier diagnosis of cholangiocarcinoma among Hispanics.
UNASSIGNED: We performed a retrospective cohort study from 2005 to 2017 among adults in a county-funded healthcare system in Harris County, Texas. Incidence rate ratios were computed to compare age-standardized rates using U.S. standard population between 2 time periods: 2005-2011 and 2012-2017.
UNASSIGNED: We identified 139 cholangiocarcinoma cases (64% intrahepatic, 36% extrahepatic). The median age at diagnosis was 57 years; 62% were Hispanic, and 56% were born outside the U.S. The incidence rate increased from 1.2 to 2.4 per 100,000 person-years (rate ratio 2.1 [95% confidence interval {CI}: 1.5, 3.0]). Hispanic individuals and those aged 40-69 years had the highest rate of incidence increase (respectively, rate ratio: 2.5 [95% CI: 1.6, 4.0] and rate ratio: 2.0 [95% CI: 1.2, 3.0]) between time periods. In 2012-2017, the risk of cholangiocarcinoma among patients with diabetes was 1.4 times relative to those without (relative risk: 1.4; 95% CI: 1.1, 1.5) and 1.2 times among those who were overweight/obese relative to those who were not (relative risk: 1.2; 95% CI: 1.1, 1.6).
UNASSIGNED: Incidence of cholangiocarcinoma doubled during the 12-year study period, with Hispanic and middle-aged individuals disproportionately affected. Individuals with diabetes mellitus and those who were overweight or obese had a high risk of being diagnosed with cholangiocarcinoma in the later time period. Further studies should focus on preventing and improving earlier diagnosis of cholangiocarcinoma among Hispanics.
摘要：
■胆管癌是一种相对罕见的恶性肿瘤，死亡率高。在美国,胆管癌的发病率增加，尤其影响年轻年龄组和西班牙裔和亚洲人。我们调查了胆管癌的发病率，少数民族人口。
■我们从2005年到2017年在哈里斯县县级资助的医疗保健系统中对成年人进行了回顾性队列研究。德克萨斯州。计算发病率比率，以比较使用美国标准人群的年龄标准化率，两个时间段：2005-2011年和2012-2017年。
■我们确定了139例胆管癌病例（肝内64%，36%的肝外)。诊断时的中位年龄为57岁；62%是西班牙裔，56％出生在美国以外地区。发病率从每100,000人年1.2增加到2.4（比率2.1[95％置信区间{CI}：1.5，3.0]）。西班牙裔人和40-69岁的人的发病率增长率最高(分别，时间段之间的比率：2.5[95%CI：1.6，4.0]和比率：2.0[95%CI：1.2，3.0]）。在2012-2017年，糖尿病患者的胆管癌风险是无糖尿病患者的1.4倍（相对风险：1.4;95％CI：1.1，1.5），超重/肥胖患者的1.2倍。
■在12年的研究期间，胆管癌的发病率翻了一番，西班牙裔和中年人受到不成比例的影响。糖尿病患者和超重或肥胖患者在后期有很高的风险被诊断为胆管癌。进一步的研究应集中在预防和改善西班牙裔胆管癌的早期诊断上。
■我们从2005年到2017年在哈里斯县县级资助的医疗保健系统中对成年人进行了回顾性队列研究。德克萨斯州。计算发病率比率，以比较使用美国标准人群的年龄标准化率，两个时间段：2005-2011年和2012-2017年。
■我们确定了139例胆管癌病例（肝内64%，36%的肝外)。诊断时的中位年龄为57岁；62%是西班牙裔，56％出生在美国以外地区。发病率从每100,000人年1.2增加到2.4（比率2.1[95％置信区间{CI}：1.5，3.0]）。西班牙裔人和40-69岁的人的发病率增长率最高(分别，时间段之间的比率：2.5[95%CI：1.6，4.0]和比率：2.0[95%CI：1.2，3.0]）。在2012-2017年，糖尿病患者的胆管癌风险是无糖尿病患者的1.4倍（相对风险：1.4;95％CI：1.1，1.5），超重/肥胖患者的1.2倍。
■在12年的研究期间，胆管癌的发病率翻了一番，西班牙裔和中年人受到不成比例的影响。糖尿病患者和超重或肥胖患者在后期有很高的风险被诊断为胆管癌。进一步的研究应集中在预防和改善西班牙裔胆管癌的早期诊断上。
