PDF(Pubmed)
Abstract：
Previous studies found seasonal variations in the incidence of retinal vascular occlusion (RVO), with more occurrence in winter. There is increasing evidence linking vitamin D deficiency and RVO. Therefore, we conducted a meta-analysis to evaluate the association between vitamin D levels and RVO. From inception to February 2024, MEDLINE and EMBASE databases were comprehensively searched. Observational studies comparing 25-hydroxyvitamin D (25(OH)D) levels between adult patients with RVO and non-RVO controls were included. We calculated pooled mean difference (MD) and pooled odds ratio (OR) with 95% confidence intervals (CI) of our data using a random-effects model and generic inverse variance method. Five studies involving 528 patients (228 patients with RVO and 300 controls were included in the meta-analysis. 25(OH)D was significantly lower in patients with RVO (pooled MD of -9.65 (95%CI -13.72 to -5.59, I2 = 92.2%). Vitamin D deficiency (serum 25(OH)D < 20) was significantly associated with RVO with the pooled OR of 14.52 (95%CI 1.72 to 122.59, I2 = 90.5). There was no difference in 25(OH)D levels between patients with central RVO and branched RVO (pooled MD of -0.94 (95%CI -3.91 to 2.03, I2 = 59.1%). In conclusion, our meta-analysis demonstrates that serum vitamin D levels were lower in patients with RVO than non-RVO controls. Clinicians could consider screening for vitamin D deficiency in patients with RVO. Further studies are warranted to determine the correlation between vitamin D levels and disease severity and the role of vitamin D supplements in these populations.
摘要：
先前的研究发现视网膜血管阻塞（RVO）发病率的季节性变化，更多发生在冬天。越来越多的证据表明维生素D缺乏和RVO有关。因此,我们进行了一项荟萃分析,以评估维生素D水平与RVO之间的关联.从成立到2024年2月，对MEDLINE和EMBASE数据库进行了全面搜索。包括比较成人RVO患者和非RVO对照患者之间25-羟基维生素D（25（OH）D）水平的观察性研究。我们使用随机效应模型和通用逆方差方法，以95％的置信区间（CI）计算了数据的合并平均差（MD）和合并比值比（OR）。5项研究涉及528例患者（228例RVO患者和300例对照者被纳入荟萃分析。RVO患者的25（OH）D显着降低（合并MD为-9.65（95CI-13.72至-5.59，I2=92.2％）。维生素D缺乏（血清25（OH）D<20）与RVO显着相关，合并OR为14.52（95CI1.72至122.59，I2=90.5）。中心性RVO和分支性RVO患者的25（OH）D水平没有差异（合并MD为-0.94（95CI-3.91至2.03，I2=59.1％）。总之,我们的荟萃分析显示,RVO患者的血清维生素D水平低于非RVO对照组.临床医生可以考虑筛查RVO患者的维生素D缺乏症。需要进一步的研究来确定维生素D水平与疾病严重程度之间的相关性以及维生素D补充剂在这些人群中的作用。
