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Abstract：
BACKGROUND: Retinopathy of prematurity (ROP) is an important cause of visual morbidity among preterm infants. The objective of the study was to assess the relationship between the initial hematological parameters of the complete blood count (CBC) and ROP development in preterm neonates.
METHODS: This retrospective cohort study was conducted in a neonatal intensive care unit in Odisha. The hematological parameters of the CBC conducted within the first 48 hours of age, demographic characteristics, neonatal morbidities, and ROP screening findings of preterm neonates (gestational age <34 weeks) were analyzed. Independent risk factors associated with ROP development were identified in a multivariate logistic regression model.
RESULTS: A total of 43 (29.1%) out of 148 neonates had any of the ROP stages (stage 1-26, 2-08, and 3-09). Birth weight (aOR 0.003; 95% CI 0.00, 0.11);hemoglobin (Hb) level (aOR 0.70; 95% CI 0.54, 0.90); presence of respiratory distress syndrome (RDS) (aOR 7.61; 95% CI 1.5, 36.39); and need for packed red blood cell (PRBC) transfusion (aOR 4.26; 95% CI 1.1, 16.44) were independently associated with ROP development. The odds of ROP were higher among the neonates with initial Hb 10.5-15.4 g/dL (OR (95% CI) 3.7(1.5, 8.9), p=0.003) and for neonates with Hb 15.4-17.3 g/dL (OR (95% CI) 2.5(1.01, 6.16), p=0.047) in comparison to neonates with initial Hb >17.3 g/dL.
CONCLUSIONS: Preterm neonates with a lower level of Hb during the early postnatal days are at higher risk for ROP development and need to be prioritized for screening.
METHODS: This retrospective cohort study was conducted in a neonatal intensive care unit in Odisha. The hematological parameters of the CBC conducted within the first 48 hours of age, demographic characteristics, neonatal morbidities, and ROP screening findings of preterm neonates (gestational age <34 weeks) were analyzed. Independent risk factors associated with ROP development were identified in a multivariate logistic regression model.
RESULTS: A total of 43 (29.1%) out of 148 neonates had any of the ROP stages (stage 1-26, 2-08, and 3-09). Birth weight (aOR 0.003; 95% CI 0.00, 0.11);hemoglobin (Hb) level (aOR 0.70; 95% CI 0.54, 0.90); presence of respiratory distress syndrome (RDS) (aOR 7.61; 95% CI 1.5, 36.39); and need for packed red blood cell (PRBC) transfusion (aOR 4.26; 95% CI 1.1, 16.44) were independently associated with ROP development. The odds of ROP were higher among the neonates with initial Hb 10.5-15.4 g/dL (OR (95% CI) 3.7(1.5, 8.9), p=0.003) and for neonates with Hb 15.4-17.3 g/dL (OR (95% CI) 2.5(1.01, 6.16), p=0.047) in comparison to neonates with initial Hb >17.3 g/dL.
CONCLUSIONS: Preterm neonates with a lower level of Hb during the early postnatal days are at higher risk for ROP development and need to be prioritized for screening.
摘要：
背景：早产儿视网膜病变（ROP）是早产儿视力发病的重要原因。该研究的目的是评估早产儿全血细胞计数（CBC）的初始血液学参数与ROP发展之间的关系。
方法：这项回顾性队列研究在奥里萨邦的新生儿重症监护病房进行。在最初的48小时内进行的CBC的血液学参数，人口特征，新生儿发病率,分析早产儿(胎龄<34周)的ROP筛查结果。在多变量逻辑回归模型中确定了与ROP发展相关的独立危险因素。
结果：148例新生儿中有43例（29.1％）具有任何ROP阶段（阶段1-26、2-08和3-09）。出生体重（aOR0.003；95％CI0.00，0.11）；血红蛋白（Hb）水平（aOR0.70；95％CI0.54，0.90）；呼吸窘迫综合征（RDS）的存在（aOR7.61；95％CI1.5，36.39）；以及需要输注红细胞（PRBC）（aOR4.26；95％CI1.1，16.44）与ROP发展独立相关。在初始Hb10.5-15.4g/dL的新生儿中，ROP的几率更高（OR（95％CI）3.7（1.5，8.9），p=0.003），对于Hb15.4-17.3g/dL的新生儿（OR（95％CI）2.5（1.01，6.16），p=0.047）与初始Hb>17.3g/dL的新生儿相比。
结论：出生后早期Hb水平较低的早产儿发生ROP的风险较高，需要优先进行筛查。
方法：这项回顾性队列研究在奥里萨邦的新生儿重症监护病房进行。在最初的48小时内进行的CBC的血液学参数，人口特征，新生儿发病率,分析早产儿(胎龄<34周)的ROP筛查结果。在多变量逻辑回归模型中确定了与ROP发展相关的独立危险因素。
结果：148例新生儿中有43例（29.1％）具有任何ROP阶段（阶段1-26、2-08和3-09）。出生体重（aOR0.003；95％CI0.00，0.11）；血红蛋白（Hb）水平（aOR0.70；95％CI0.54，0.90）；呼吸窘迫综合征（RDS）的存在（aOR7.61；95％CI1.5，36.39）；以及需要输注红细胞（PRBC）（aOR4.26；95％CI1.1，16.44）与ROP发展独立相关。在初始Hb10.5-15.4g/dL的新生儿中，ROP的几率更高（OR（95％CI）3.7（1.5，8.9），p=0.003），对于Hb15.4-17.3g/dL的新生儿（OR（95％CI）2.5（1.01，6.16），p=0.047）与初始Hb>17.3g/dL的新生儿相比。
结论：出生后早期Hb水平较低的早产儿发生ROP的风险较高，需要优先进行筛查。
