PDF(Pubmed)
Abstract：
UNASSIGNED: Non-union of long bones is a common challenge in the treatment of fractures. Bone grafting is commonly used to treat atrophic non-union, but mechanical displacement of the graft may occur, resulting in delay or failure of treatment. Fibrin glue has demonstrated positive results in management of bone defects in neurosurgery and oromaxillary facial surgery, however, there has yet to be any study on its use in long bone fractures.
UNASSIGNED: We conducted a prospective randomised controlled trial at a single tertiary centre involving adult patients with long bone fractures that had undergone non-union and requiring bone grafting only. Autologous iliac crest bone graft was applied to the debrided non-union site, with additional fibrin glue applied for the intervention arm. Patients were followed-up with serial radiographs until clinical and radiographical union.
UNASSIGNED: Ten patients (3 male, 7 female), of mean age 41.7 (19 - 63) were recruited over five years, with one drop out. Eight out of nine fractures united after treatment. One patient underwent hypertrophic non-union requiring re-fixation and bone grafting. There was no difference in the time to union for patients in the fibrin glue group (19.5 weeks) versus the control group (18.75 weeks) (p=0.86). There were no complications sustained from usage of fibrin glue.
UNASSIGNED: Fibrin glue appears to be a safe adjunct for treatment of non-union of long bone fractures across varying fracture sites by holding the bone graft in place despite not demonstrating a faster time to union.
UNASSIGNED: We conducted a prospective randomised controlled trial at a single tertiary centre involving adult patients with long bone fractures that had undergone non-union and requiring bone grafting only. Autologous iliac crest bone graft was applied to the debrided non-union site, with additional fibrin glue applied for the intervention arm. Patients were followed-up with serial radiographs until clinical and radiographical union.
UNASSIGNED: Ten patients (3 male, 7 female), of mean age 41.7 (19 - 63) were recruited over five years, with one drop out. Eight out of nine fractures united after treatment. One patient underwent hypertrophic non-union requiring re-fixation and bone grafting. There was no difference in the time to union for patients in the fibrin glue group (19.5 weeks) versus the control group (18.75 weeks) (p=0.86). There were no complications sustained from usage of fibrin glue.
UNASSIGNED: Fibrin glue appears to be a safe adjunct for treatment of non-union of long bone fractures across varying fracture sites by holding the bone graft in place despite not demonstrating a faster time to union.
摘要：
■长骨不愈合是骨折治疗中的一个共同挑战。骨移植通常用于治疗萎缩性骨不连，但是移植物可能会发生机械移位，导致治疗延误或失败。纤维蛋白胶在神经外科和口腔颌面外科的骨缺损治疗中显示出积极的结果。然而,关于其在长骨骨折中的应用还没有任何研究。
■我们在一个三级中心进行了一项前瞻性随机对照试验，涉及长骨骨折不愈合且仅需要植骨的成年患者。自体髂骨骨移植到清创不愈合部位，与额外的纤维蛋白胶应用于干预臂。对患者进行连续X光片随访，直到临床和影像学结合。
■10名患者（3名男性，7女），平均年龄41.7(19-63)的人被招募了五年，一个人退出。9个骨折中有8个在治疗后合并。一名患者经历了肥厚性不连，需要重新固定和植骨。纤维蛋白胶组（19.5周）与对照组（18.75周）的患者愈合时间没有差异（p=0.86）。使用纤维蛋白胶没有并发症。
■纤维蛋白胶似乎是治疗不同骨折部位的长骨骨折不愈合的安全辅助手段，尽管没有显示更快的愈合时间。
■我们在一个三级中心进行了一项前瞻性随机对照试验，涉及长骨骨折不愈合且仅需要植骨的成年患者。自体髂骨骨移植到清创不愈合部位，与额外的纤维蛋白胶应用于干预臂。对患者进行连续X光片随访，直到临床和影像学结合。
■10名患者（3名男性，7女），平均年龄41.7(19-63)的人被招募了五年，一个人退出。9个骨折中有8个在治疗后合并。一名患者经历了肥厚性不连，需要重新固定和植骨。纤维蛋白胶组（19.5周）与对照组（18.75周）的患者愈合时间没有差异（p=0.86）。使用纤维蛋白胶没有并发症。
■纤维蛋白胶似乎是治疗不同骨折部位的长骨骨折不愈合的安全辅助手段，尽管没有显示更快的愈合时间。
