PDF(Pubmed)
Abstract：
UNASSIGNED: Sepsis is a major global health affecting millions worldwide, hence understanding its contributing factors becomes paramount. This cross-sectional study at a tertiary care center explores the relationship between iron profile, vitamin D levels, and outcomes in sepsis and septic shock patients. The primary objective was to explore the prevalence of iron profile and vitamin D parameters during early intensive care unit (ICU) admission and their association with 28-day mortality.
UNASSIGNED: Spanning 18 months, the study enrolled adult patients meeting sepsis or septic shock criteria at the ICU. Data collection included demographic information, clinical characteristics, and blood samples for iron profile and vitamin D levels at admission. Disease severity was assessed using sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores, and treatment was administered as per surviving sepsis-3 guidelines.
UNASSIGNED: The research involved 142 participants, uncovering prevalent organisms such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Noteworthy connections to mortality were identified for factors including vasopressor support, ICU stay duration, SOFA score, and APACHE-II score. Interestingly, age, gender, and vitamin D levels showed no significant associations. However, the study did reveal a significant association between iron, ferritin, and transferrin saturation levels with increased 28-day mortality.
UNASSIGNED: Our study concluded that low Iron, elevated ferritin, and decreased transferrin saturation levels maintained associations with the outcome of interest. While no such relationship was established with vitamin D levels. These results suggest potential implications for patient management and prognosis, warranting further exploration in future research.
UNASSIGNED: Bairwa M, Jatteppanavar B, Kant R, Singh M, Choudhury A. Impact of Iron Profile and Vitamin D Levels on Clinical Outcomes in Patients with Sepsis and Septic Shock: A Cross-sectional Analysis at a Tertiary Care Center. Indian J Crit Care Med 2024;28(6):569-574.
UNASSIGNED: Spanning 18 months, the study enrolled adult patients meeting sepsis or septic shock criteria at the ICU. Data collection included demographic information, clinical characteristics, and blood samples for iron profile and vitamin D levels at admission. Disease severity was assessed using sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores, and treatment was administered as per surviving sepsis-3 guidelines.
UNASSIGNED: The research involved 142 participants, uncovering prevalent organisms such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Noteworthy connections to mortality were identified for factors including vasopressor support, ICU stay duration, SOFA score, and APACHE-II score. Interestingly, age, gender, and vitamin D levels showed no significant associations. However, the study did reveal a significant association between iron, ferritin, and transferrin saturation levels with increased 28-day mortality.
UNASSIGNED: Our study concluded that low Iron, elevated ferritin, and decreased transferrin saturation levels maintained associations with the outcome of interest. While no such relationship was established with vitamin D levels. These results suggest potential implications for patient management and prognosis, warranting further exploration in future research.
UNASSIGNED: Bairwa M, Jatteppanavar B, Kant R, Singh M, Choudhury A. Impact of Iron Profile and Vitamin D Levels on Clinical Outcomes in Patients with Sepsis and Septic Shock: A Cross-sectional Analysis at a Tertiary Care Center. Indian J Crit Care Med 2024;28(6):569-574.
摘要：
■脓毒症是影响全球数百万人的主要全球健康，因此，了解其影响因素变得至关重要。这项在三级护理中心进行的横断面研究探讨了铁轮廓之间的关系，维生素D水平,以及脓毒症和脓毒性休克患者的预后。主要目的是探讨早期重症监护病房（ICU）住院期间铁和维生素D参数的患病率及其与28天死亡率的关系。
■跨越18个月，本研究纳入ICU符合脓毒症或脓毒性休克标准的成年患者.数据收集包括人口统计信息，临床特征,入院时的铁和维生素D水平的血液样本。使用序贯器官衰竭评估（SOFA）和急性生理学和慢性健康评估II（APACHEII）评分评估疾病严重程度，按照存活的脓毒症-3指南进行治疗。
■这项研究涉及142名参与者，发现流行的生物体，如鲍曼不动杆菌，铜绿假单胞菌,和肺炎克雷伯菌.确定了与死亡率的值得注意的联系，包括血管加压药支持，ICU住院时间,SOFA得分,和APACHE-II得分。有趣的是,年龄,性别,和维生素D水平没有显着关联。然而,这项研究确实揭示了铁之间的显著关联，铁蛋白,和转铁蛋白饱和度水平增加28天死亡率。
■我们的研究得出结论，低铁，铁蛋白升高,转铁蛋白饱和度降低与感兴趣的结果保持相关性。虽然与维生素D水平没有建立这种关系。这些结果表明对患者管理和预后的潜在影响，值得在未来的研究中进一步探索。
■BairwaM,JatteppanavarB,康德R,辛格M,ChoudhuryA.铁谱和维生素D水平对脓毒症和脓毒症休克患者临床结局的影响：三级护理中心的横断面分析。印度J暴击护理中心2024；28（6）：569-574。
■跨越18个月，本研究纳入ICU符合脓毒症或脓毒性休克标准的成年患者.数据收集包括人口统计信息，临床特征,入院时的铁和维生素D水平的血液样本。使用序贯器官衰竭评估（SOFA）和急性生理学和慢性健康评估II（APACHEII）评分评估疾病严重程度，按照存活的脓毒症-3指南进行治疗。
■这项研究涉及142名参与者，发现流行的生物体，如鲍曼不动杆菌，铜绿假单胞菌,和肺炎克雷伯菌.确定了与死亡率的值得注意的联系，包括血管加压药支持，ICU住院时间,SOFA得分,和APACHE-II得分。有趣的是,年龄,性别,和维生素D水平没有显着关联。然而,这项研究确实揭示了铁之间的显著关联，铁蛋白,和转铁蛋白饱和度水平增加28天死亡率。
■我们的研究得出结论，低铁，铁蛋白升高,转铁蛋白饱和度降低与感兴趣的结果保持相关性。虽然与维生素D水平没有建立这种关系。这些结果表明对患者管理和预后的潜在影响，值得在未来的研究中进一步探索。
■BairwaM,JatteppanavarB,康德R,辛格M,ChoudhuryA.铁谱和维生素D水平对脓毒症和脓毒症休克患者临床结局的影响：三级护理中心的横断面分析。印度J暴击护理中心2024；28（6）：569-574。
