PDF(Pubmed)
Abstract：
Autologous Platelet-rich fibrin (PRF) is an amalgam of fibrin mesh, platelets and growth factors that favour wound healing. It can be easily used as a graft material in myringoplasty, making it a promising, easy to harvest and cost effective alternative compared to cartilage or fascia graft used in conventional myringoplasty. 50 patients of small to medium, dry central perforation underwent myringoplasty using PRF graft (Group 1). Results were compared to 50 patients with similar small to medium perforations who underwent conventional transcanal myringoplasty using temporalis fascia graft (Group 2): Outcome of surgery was measured by closure of perforation and improvement in hearing at 3 months. In group 1, overall closure rate was 70% while in group 2 it was 96%. For both small and medium perforations healing was significantly higher in group 2 compared to group 1, (100% vs 87.5%) for small perforations and (95.45% vs 66.67%) for medium perforations. Hearing gain was comparable in both groups in patients in whom healing of perforation occurred. PRF stands as a suitable graft material for closure of small perforations, but, lack of rigidity and early disintegration of the graft makes it less suitable for larger perforations compared to other conventional grafts such as temporalis fascia.
摘要：
自体富血小板纤维蛋白（PRF）是纤维蛋白网的混合物，有利于伤口愈合的血小板和生长因子。它可以很容易地用作鼓膜成形术的移植材料，使它成为一个有希望的，与常规鼓膜成形术中使用的软骨或筋膜移植物相比，易于收获且具有成本效益的替代方法。50名中小型患者，干燥的中央穿孔使用PRF移植物进行了鼓膜成形术（第1组）。将结果与50例使用颞肌筋膜移植物接受常规经膜鼓膜成形术的中小穿孔相似的患者进行比较（第2组）：通过3个月时穿孔的闭合和听力的改善来测量手术结果。在第1组中，总体闭合率为70％，而在第2组中为96％。对于小穿孔和中等穿孔，第2组的愈合明显高于第1组，小穿孔（100％vs87.5％）和中等穿孔（95.45％vs66.67％）。在发生穿孔愈合的患者中，两组的听力增益相当。PRF是封闭小穿孔的合适移植材料，但是,与其他常规移植物（例如颞筋膜）相比，移植物缺乏刚性和早期崩解使其不适合较大的穿孔。
