PDF(Pubmed)
Abstract：
UNASSIGNED: Age-related cognitive decline is accelerated by vascular risk factors for cerebral small vessel disease. However, the association of vascular risk factors with cerebral small vessel disease contributing to the sex differences in cognitive decline remains unclear.
UNASSIGNED: The purpose of this study was to evaluate sex differences in cognitive decline and the association between vascular risk factors and cognitive decline by sex.
UNASSIGNED: We used data from the UK Biobank (>55 years of age; n = 19,067) to assess cognitive tests (executive function, processing speed, and memory) while adjusting for baseline measurements to examine how vascular risk factors affect cognition. A univariate regression analysis was used to assess sex differences at the first time point (2014). A repeated measure analysis with a mixed effect model was used to determine cognitive decline (between 2014 and 2019). Any significant interaction between vascular risk factors and sex was investigated.
UNASSIGNED: Females had lower scores in all 3 domains at the first cognitive tests (2014). We found a significant sex-by-time interaction over a 5-year period in matrix pattern completion (P = 0.03). After adjusting for vascular risk factors, this interaction was reduced (P = 0.08). High low-density lipoprotein, low education, and high blood pressure had a greater effect on the rate of cognitive decline in the executive function for females compared to males for the sex∗vascular risk factor interaction (P < 0.05).
UNASSIGNED: The rate of cognitive decline did not differ significantly between males and females. However, the impact of several vascular risk factors on cognitive decline was greater in females than in males.
UNASSIGNED: The purpose of this study was to evaluate sex differences in cognitive decline and the association between vascular risk factors and cognitive decline by sex.
UNASSIGNED: We used data from the UK Biobank (>55 years of age; n = 19,067) to assess cognitive tests (executive function, processing speed, and memory) while adjusting for baseline measurements to examine how vascular risk factors affect cognition. A univariate regression analysis was used to assess sex differences at the first time point (2014). A repeated measure analysis with a mixed effect model was used to determine cognitive decline (between 2014 and 2019). Any significant interaction between vascular risk factors and sex was investigated.
UNASSIGNED: Females had lower scores in all 3 domains at the first cognitive tests (2014). We found a significant sex-by-time interaction over a 5-year period in matrix pattern completion (P = 0.03). After adjusting for vascular risk factors, this interaction was reduced (P = 0.08). High low-density lipoprotein, low education, and high blood pressure had a greater effect on the rate of cognitive decline in the executive function for females compared to males for the sex∗vascular risk factor interaction (P < 0.05).
UNASSIGNED: The rate of cognitive decline did not differ significantly between males and females. However, the impact of several vascular risk factors on cognitive decline was greater in females than in males.
摘要：
■脑小血管疾病的血管危险因素加速了与年龄相关的认知能力下降。然而,血管危险因素与脑小血管疾病之间的关联导致认知功能下降的性别差异尚不清楚.
■这项研究的目的是评估认知功能下降的性别差异以及血管危险因素与认知功能下降之间的联系。
■我们使用来自英国生物库的数据（>55岁；n=19,067）来评估认知测试（执行功能，处理速度,和记忆），同时调整基线测量值，以检查血管危险因素如何影响认知。在第一时间点(2014年)使用单变量回归分析来评估性别差异。使用混合效应模型的重复测量分析来确定认知下降（2014年至2019年）。研究了血管危险因素与性别之间的任何显着的相互作用。
■在第一次认知测试（2014年）中，女性在所有3个领域的得分均较低。我们发现，在5年的时间内，矩阵模式的完成存在显着的按时间性别的相互作用（P=0.03）。调整血管危险因素后，这种相互作用减少(P=0.08).高低密度脂蛋白，低教育,与男性相比，高血压对女性执行功能的认知下降率的影响更大。*血管危险因素相互作用（P<0.05）。
■男性和女性之间的认知下降率没有显着差异。然而,几种血管危险因素对认知功能下降的影响在女性中大于男性.
■这项研究的目的是评估认知功能下降的性别差异以及血管危险因素与认知功能下降之间的联系。
■我们使用来自英国生物库的数据（>55岁；n=19,067）来评估认知测试（执行功能，处理速度,和记忆），同时调整基线测量值，以检查血管危险因素如何影响认知。在第一时间点(2014年)使用单变量回归分析来评估性别差异。使用混合效应模型的重复测量分析来确定认知下降（2014年至2019年）。研究了血管危险因素与性别之间的任何显着的相互作用。
■在第一次认知测试（2014年）中，女性在所有3个领域的得分均较低。我们发现，在5年的时间内，矩阵模式的完成存在显着的按时间性别的相互作用（P=0.03）。调整血管危险因素后，这种相互作用减少(P=0.08).高低密度脂蛋白，低教育,与男性相比，高血压对女性执行功能的认知下降率的影响更大。*血管危险因素相互作用（P<0.05）。
■男性和女性之间的认知下降率没有显着差异。然而,几种血管危险因素对认知功能下降的影响在女性中大于男性.
