PDF(Pubmed)
Abstract：
Diabetic wounds are more complex than normal chronic wounds because of factors such as hypoxia, reduced local angiogenesis, and prolonged inflammation phase. Fibrous proteins, including collagen, fibrin, laminin, fibronectin, elastin etc., possess excellent inherent properties that make them highly advantageous in the area of wound healing. Accumulating evidence suggests that they contribute to the healing process of diabetic wounds by facilitating the repair and remodel of extracellular matrix, stimulating the development of vascular and granulation tissue, and so on. However, there is currently a lack of a comprehensive review of the application of these proteins in diabetes wounds. An overview of fibrous protein characteristics and the alterations linked to diabetic wounds is given in this article\'s initial section. Next is a summary of the advanced applications of fibrous proteins in the last five years, including acellular dermal matrix, hydrogel, foam, scaffold, and electrospun nanofibrous membrane. These dressings have the ability to actively promote healing in addition to just covering wounds compared to traditional wound dressings like gauze or bandage. Research on fibrous proteins and their role in diabetic wound healing may result in novel therapeutic modalities that lower the incidence of diabetic wounds and thereby enhance the health of diabetic patients.
摘要：
由于缺氧等因素，糖尿病伤口比正常慢性伤口更复杂，减少局部血管生成，炎症期延长。纤维状蛋白质,包括胶原蛋白,纤维蛋白,层粘连蛋白,纤连蛋白,弹性蛋白等.,具有优异的固有特性，使它们在伤口愈合领域非常有利。越来越多的证据表明，它们通过促进细胞外基质的修复和重塑来促进糖尿病伤口的愈合过程。刺激血管和肉芽组织的发育，等等。然而,目前缺乏对这些蛋白质在糖尿病伤口中的应用的全面审查。本文的初始部分概述了纤维蛋白的特征以及与糖尿病伤口有关的改变。接下来是最近五年来纤维蛋白的先进应用的总结，包括脱细胞真皮基质，水凝胶，泡沫，脚手架,和静电纺丝纳米纤维膜。与传统的伤口敷料如纱布或绷带相比,这些敷料除了仅覆盖伤口之外还具有积极促进愈合的能力。对纤维蛋白及其在糖尿病伤口愈合中的作用的研究可能会导致新的治疗方式，从而降低糖尿病伤口的发生率，从而增强糖尿病患者的健康。
