UNASSIGNED: Activin A and FSTL-3 levels were assessed in 59 patients undergoing liver surgery. Using receiver operating characteristic analysis, we evaluated the predictive potential of activin A, FSTL-3, and their ratio.
UNASSIGNED: While perioperative dynamics of activin A and FSTL3 were significantly affected by hepatic resection (activin A P = .045, FSTL-3 P = .005), their functionally relevant ratio did not significantly change (P = .528). Neither activin A nor FSTL-3 alone but only their ratio exhibited a significant predictive potential for PHLF (area under the curve: 0.789, P = .038). Patients with low preoperative activin A/FSTL-3 ratio were found to more frequently suffer from PHLF (0.017) and morbidity (0.005).
UNASSIGNED: Activin A/FSTL-3 ratio predicts PHLF and morbidity. Its significance in preoperative patient assessment needs to be further validated in larger, independent cohorts.
■在59例接受肝脏手术的患者中评估了激活素A和FSTL-3的水平。利用接收机工作特性分析,我们评估了激活素A的预测潜力,FSTL-3及其比率。
■虽然激活素A和FSTL3的围手术期动力学受到肝切除术的显着影响(激活素AP=.045,FSTL-3P=.005),其功能相关比率无显著变化(P=.528).单独的活化素A和FSTL-3均未表现出显著的PHLF预测潜力(曲线下面积:0.789,P=.038)。术前激活素A/FSTL-3比率较低的患者更容易患PHLF(0.017)和发病率(0.005)。
■激活素A/FSTL-3比值可预测PHLF和发病率。其在术前患者评估中的意义有待进一步验证,独立队列。