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Abstract：
UNASSIGNED: This scoping review and meta-analysis aimed to map the evidence regarding prognostic factors in Chinese patients with immunoglobulin light chain (AL) amyloidosis and to identify current research gaps.
UNASSIGNED: We searched EMBASE, PubMed, and CNKI databases from their inception to 15 September 2021. All studies investigated the association between any prognostic factor and target outcomes, including overall survival (OS), progression-free survival (PFS), and end-stage renal disease (ESRD) in Chinese patients with AL amyloidosis.
UNASSIGNED: This scoping review included 52 studies, of which 44 with 6,432 patients contributed to the multivariate prognostic analysis. Multivariate analysis identified a total of 106 factors that correlated with OS, 16 factors with PFS, and 18 factors with ESRD. Five prognostic factors were significantly associated with PFS, and 11 prognostic factors were significantly associated with ESRD. Meta-analysis was only available for prognostic factors without heterogeneous cutoff values, for which hazard ratios (HRs) and their 95% confidence intervals (CIs) were reported. Meta-analysis showed that bone marrow plasma cells (BMCs) (HR: 1.96, 95% CI: 1.21-3.19, p < 0.05) and interventricular septal thickness (IVST) (HR: 1.23, 95% CI: 1.10-1.38, p < 0.05) were independently associated with OS.
UNASSIGNED: The significant prognostic factors associated with OS, PFS, and ESRD in Chinese patients with AL amyloidosis were related to plasma cell tumor load, biological characteristics, cardiac involvement, renal involvement, population characteristics, and treatment. Further studies should explore additional prognostic factors in patients with AL amyloidosis to develop prognostic models.
The significant prognostic factors associated with OS, PFS, and ESRD in Chinese patients with AL amyloidosis were related to plasma cell tumor load, biological characteristics, cardiac involvement, renal involvement, population characteristics, and treatment.Meta-analysis showed there was a significant association between BMCs or interventricular septal thickness and OS.
UNASSIGNED: We searched EMBASE, PubMed, and CNKI databases from their inception to 15 September 2021. All studies investigated the association between any prognostic factor and target outcomes, including overall survival (OS), progression-free survival (PFS), and end-stage renal disease (ESRD) in Chinese patients with AL amyloidosis.
UNASSIGNED: This scoping review included 52 studies, of which 44 with 6,432 patients contributed to the multivariate prognostic analysis. Multivariate analysis identified a total of 106 factors that correlated with OS, 16 factors with PFS, and 18 factors with ESRD. Five prognostic factors were significantly associated with PFS, and 11 prognostic factors were significantly associated with ESRD. Meta-analysis was only available for prognostic factors without heterogeneous cutoff values, for which hazard ratios (HRs) and their 95% confidence intervals (CIs) were reported. Meta-analysis showed that bone marrow plasma cells (BMCs) (HR: 1.96, 95% CI: 1.21-3.19, p < 0.05) and interventricular septal thickness (IVST) (HR: 1.23, 95% CI: 1.10-1.38, p < 0.05) were independently associated with OS.
UNASSIGNED: The significant prognostic factors associated with OS, PFS, and ESRD in Chinese patients with AL amyloidosis were related to plasma cell tumor load, biological characteristics, cardiac involvement, renal involvement, population characteristics, and treatment. Further studies should explore additional prognostic factors in patients with AL amyloidosis to develop prognostic models.
The significant prognostic factors associated with OS, PFS, and ESRD in Chinese patients with AL amyloidosis were related to plasma cell tumor load, biological characteristics, cardiac involvement, renal involvement, population characteristics, and treatment.Meta-analysis showed there was a significant association between BMCs or interventricular septal thickness and OS.
摘要：
■本范围综述和荟萃分析旨在绘制有关中国免疫球蛋白轻链（AL）淀粉样变性患者预后因素的证据，并确定当前的研究空白。
■我们搜索了EMBASE，PubMed,和CNKI数据库从成立到2021年9月15日。所有研究都调查了任何预后因素与目标结果之间的关联。包括总生存期(OS)，无进展生存期（PFS），中国AL淀粉样变性患者的终末期肾病（ESRD）。
■这项范围审查包括52项研究，其中44例6,432例患者参与了多变量预后分析。多变量分析确定了总共106个与OS相关的因素，PFS的16个因素，和ESRD的18个因素。五个预后因素与PFS显著相关，11个预后因素与ESRD显著相关。荟萃分析仅适用于没有异质性临界值的预后因素，报告了风险比(HRs)及其95%置信区间(CIs).Meta分析显示，骨髓浆细胞（BMC）（HR：1.96，95％CI：1.21-3.19，p<0.05）和室间隔厚度（IVST）（HR：1.23，95％CI：1.10-1.38，p<0.05）与OS独立相关。
■与OS相关的重要预后因素，PFS,中国AL淀粉样变性患者的ESRD与浆细胞肿瘤负荷有关，生物学特性，心脏受累,肾受累,人口特征，和治疗。进一步的研究应探索AL淀粉样变性患者的其他预后因素，以建立预后模型。
与OS相关的重要预后因素，PFS,中国AL淀粉样变性患者的ESRD与浆细胞肿瘤负荷有关，生物学特性，心脏受累,肾受累,人口特征，和治疗。Meta分析显示，BMC或室间隔厚度与OS之间存在显着相关性。
■我们搜索了EMBASE，PubMed,和CNKI数据库从成立到2021年9月15日。所有研究都调查了任何预后因素与目标结果之间的关联。包括总生存期(OS)，无进展生存期（PFS），中国AL淀粉样变性患者的终末期肾病（ESRD）。
■这项范围审查包括52项研究，其中44例6,432例患者参与了多变量预后分析。多变量分析确定了总共106个与OS相关的因素，PFS的16个因素，和ESRD的18个因素。五个预后因素与PFS显著相关，11个预后因素与ESRD显著相关。荟萃分析仅适用于没有异质性临界值的预后因素，报告了风险比(HRs)及其95%置信区间(CIs).Meta分析显示，骨髓浆细胞（BMC）（HR：1.96，95％CI：1.21-3.19，p<0.05）和室间隔厚度（IVST）（HR：1.23，95％CI：1.10-1.38，p<0.05）与OS独立相关。
■与OS相关的重要预后因素，PFS,中国AL淀粉样变性患者的ESRD与浆细胞肿瘤负荷有关，生物学特性，心脏受累,肾受累,人口特征，和治疗。进一步的研究应探索AL淀粉样变性患者的其他预后因素，以建立预后模型。
与OS相关的重要预后因素，PFS,中国AL淀粉样变性患者的ESRD与浆细胞肿瘤负荷有关，生物学特性，心脏受累,肾受累,人口特征，和治疗。Meta分析显示，BMC或室间隔厚度与OS之间存在显着相关性。
