Abstract：
Tissue contamination with persistent organic pollutants (POPs) in organisms proved possible to comprehensively characterize in a single test by combining gas chromatography and high-resolution accurate mass spectrometry. Adipose tissue samples were collected from two Caspian seals (Pusa caspica Gmelin, 1788) found dead on the Caspian Sea shore in 2020. Organochlorine pesticides, primarily DDT and HCH, and polychlorinated biphenyls (PCBs) were major pollutants found in the Caspian seals. The distribution of metabolites indicated the absence of recent pesticide use. The PCB content was relatively high, but still at the lower limit of the range of values determined previously, as was also the case with pesticides. Chlordanes, polychlorinated naphthalenes, and polybrominated diphenyl ethers were detected in minor quantities and were therefore not considered to be major pollutants of the Caspian seal. The pollutant levels were below a threshold at which a distinct effect on seal health can be expected. High-resolution accurate mass (HRAM) spectrometry was found to provide a convenient tool for both targeted and nontargeted analyses of a wide range of organic pollutants in a single experiment.
摘要：
生物中持久性有机污染物（POPs）的组织污染被证明可以通过结合气相色谱和高分辨率精确质谱在一次测试中全面表征。从两个里海海豹（PusacaspicaGmelin，1788）于2020年在里海沿岸被发现死亡。有机氯杀虫剂,主要是滴滴涕和六氯环己烷，多氯联苯（PCBs）是在里海海豹中发现的主要污染物。代谢物的分布表明最近没有使用杀虫剂。PCB含量相对较高，但仍处于先前确定的值范围的下限，杀虫剂也是如此。氯丹,多氯萘，和多溴联苯醚被检测到少量，因此不被认为是里海海豹的主要污染物。污染物水平低于可以预期对海豹健康产生明显影响的阈值。发现高分辨率精确质谱（HRAM）光谱法为在单个实验中对各种有机污染物进行靶向和非靶向分析提供了方便的工具。
