Abstract：
Hepatocellular carcinoma, also referred to as HCC, is the most frequent form of primary liver cancer. It is anticipated that the discovery of the molecular pathways related with HCC would open up new possibilities for the treatment of HCC.WGCNA (Weighted gene co-expression network analysis) and molecular docking analysis were used to study the structural characteristics of POU2AF1 recombinant protein and its interaction with related proteins. Normal samples were placed in one group, and tumor samples were placed in another group inside the GEO database. We continued our investigation of the DEGs by performing an enrichment analysis using GO and KEGG. The GSCA platform is utilized in the process of doing an analysis of the connection between gene expression and medication sensitivity. In the end, the core target and the active molecule were both given the green light for a molecular docking investigation. POU2AF1 is being considered as a possible therapeutic target for HCC, and the results of our work have presented novel concepts for the treatment of HCC.
摘要：
肝细胞癌,也被称为HCC，是原发性肝癌的最常见形式。预计与HCC相关的分子途径的发现将为HCC的治疗开辟新的可能性。采用WGCNA(加权基因共表达网络分析)和分子对接分析研究POU2AF1重组蛋白的结构特征及其与相关蛋白的相互作用。将正常样本放在一组中，和肿瘤样本被放置在GEO数据库内的另一组中。我们通过使用GO和KEGG进行富集分析，继续对DEGs进行调查。GSCA平台用于分析基因表达和药物敏感性之间的联系。最后,核心靶标和活性分子均获得了分子对接研究的绿灯。POU2AF1被认为是肝癌的可能治疗靶点，我们的工作结果为HCC的治疗提出了新的概念。
