Abstract：
Multidrug -resistant tuberculosis (MDRTB) is a serious threat to mankind. India has the highest number of MDRTB cases, although majority remain undiagnosed due to inadequate diagnostic infrastructure, leading to increased community transmission and mortality. This one-year observational retrospective study highlighted the effectiveness of the National Tuberculosis Elimination Program (NTEP) for prompt detection of drug-resistant TB by GeneXpert MTB/RIF assay and revealed its associated clinico-epidemiological factors. The overall detection rates of MTB and RRTB were 20.70 % and 20.86 % respectively. The pediatric population had 7.69 % rifampicin resistance, and HIV was strongly associated with the development of TB and RRTB (P < 0.01).
摘要：
耐多药结核病（MDRTB）是对人类的严重威胁。印度的MDRTB案件数量最多，尽管由于诊断基础设施不足，大多数仍未被诊断，导致社区传播和死亡率增加。这项为期一年的观察性回顾性研究强调了国家结核病消除计划（NTEP）通过GeneXpertMTB/RIF测定法迅速检测耐药结核病的有效性，并揭示了其相关的临床流行病学因素。MTB和RRTB的总检出率分别为20.70%和20.86%。儿科人群对利福平的耐药率为7.69％，HIV与TB和RRTB的发生密切相关(P<0.01)。
