METHODS: We retrospectively analyzed patients with newly diagnosed OCSCC from two institutions, totaling 348 patients. Involvement of LNLs I-V was recorded individually based on pathology after neck dissection with clinicopathological factors. The dataset is publicly available in a previously developed web-app, which allows querying patients with specific combinations of co-involved LNLs and tumor characteristics.
RESULTS: Ipsilateral involvement prevalence of levels I-III was higher for advanced T-category (T3/T4) patients (32 %, 38 %, 14 %) compared to early (T1/T2) patients (14 %, 23 %, 11 %). Involvement of level I increased the involvement probability in levels II and III. Similarly, involvement of level II increased the involvement probability in levels I and III. However, there was significant isolated involvement of level I or II. Advanced nodal involvement (>1 LNL involved) was more frequent for patients with extracapsular extension. Overall contralateral involvement in levels I-III was 7 %, 4 %, 3 % and more frequent for more advanced ipsilateral involvement and for midline-crossing tumors. Involvement of levels IV and V was rare: 3 % ipsilateral and 1 % contralateral in both levels.
CONCLUSIONS: Detailed quantification of LNL involvement in OCSCC depending on involvement of adjacent LNLs and clinicopathological factors may allow further personalizing guidelines on elective nodal treatment.
方法:我们回顾性分析了来自两个机构的新诊断OCSCC患者,共348名患者。根据颈淋巴结清扫术后病理和临床病理因素,分别记录LNLsI-V的参与情况。该数据集在以前开发的Web应用程序中公开可用,这允许查询具有共同参与的LNLs和肿瘤特征的特定组合的患者。
结果:晚期T类(T3/T4)患者的I-III级同侧受累率较高(32%,38%,14%)与早期(T1/T2)患者(14%,23%,11%)。I级的参与增加了II级和III级的参与概率。同样,II级的参与增加了I级和III级的参与概率.然而,有显著的I级或II级孤立参与.对于囊外延伸的患者,晚期淋巴结受累(>1LNL受累)更为常见。I-III级对侧总体受累为7%,4%,3%,对于更晚期的同侧受累和中线交叉肿瘤,频率更高。IV和V级的参与很少见:在两个级别中,同侧为3%,对侧为1%。
结论:根据邻近LNL的受累情况和临床病理因素,对OCSCC中LNL受累情况进行详细量化,可能允许进一步对选择性淋巴结治疗进行个性化指导。