PDF(Pubmed)
Abstract：
In the antibiotic-free era, traditional antibiotics have been suggested as alternatives to antibiotic-based growth promoters. Among the various methods, self-nano-emulsifying drug delivery systems (SNEDDS) are increasingly utilized to improve the bioavailability of oils containing essential substances. In this study, we evaluated the effects of black soldier fly oil (BSFO) SNEDDS in chicken drinking water on growth performance, small intestine histomorphology, and poultry health status. We divided 225 male Indian River strain broiler chickens into five treatment groups, each consisting of 5 replicates. The chickens were reared from to 0 to 35 d of age in a controlled environmental housing system. The BSFO SNEDDS was administered via drinking water. Treatments included ordinary drinking water (P1), bacitracin (P2), and 10 mL/L (P3), 20 mL/L (P4), and 30 mL/L (P5) BSFO SNEDDS. The observed parameters included growth performance, carcass yield, blood hematology, intestinal histomorphology, digestive microflora, and immunoglobulin (Ig) levels. Data were analyzed using analysis of variance (ANOVA) and Duncan\'s test. The results indicated that administering BSFO SNEDDS via drinking water improved feed conversion (P < 0.05), enhanced the performance index (P < 0.05), increased carcass percentage (P < 0.001), and increased the weight of the carcass parts. Additionally, it increased villus height (P < 0.01), lowered jejunal pH (P < 0.001), reduced pathogenic bacteria in the jejunum, and decreased the leukocyte count. BSFO SNEDDS in drinking water is expected to be used as a traditional antibiotic with the potential to replace synthetic antibiotic growth promoters in broiler chickens.
摘要：
在无抗生素时代,传统抗生素已被建议作为基于抗生素的生长促进剂的替代品。在各种方法中，自纳米乳化药物递送系统(SNEDDS)越来越多地用于提高含有必需物质的油的生物利用度。在这项研究中,我们评估了鸡饮用水中黑兵蝇油（BSFO）SNEDDS对生长性能的影响，小肠组织形态学,和家禽健康状况。我们将225只雄性印度河肉鸡分为五个处理组，每个由5个重复组成。在受控的环境住房系统中饲养了0至35d的鸡。BSFOSNEDDS通过饮用水施用。治疗包括普通饮用水(P1)，杆菌肽（P2），和10mL/L（P3），20mL/L(P4),和30mL/L(P5)BSFOSNEDDS。观察到的参数包括生长性能，car体产量，血液血液学,肠道组织形态学,消化微生物,免疫球蛋白（Ig）水平。使用方差分析(ANOVA)和Duncan检验分析数据。结果表明，通过饮用水施用BSFOSNEDDS可以提高饲料转化率（P<0.05）。提高了性能指标(P<0.05)，car体百分比增加（P<0.001），增加了屠体部分的重量。此外,增加绒毛高度(P<0.01),空肠pH值降低（P<0.001），减少空肠中的致病菌，并减少了白细胞计数。饮用水中的BSFOSNEDDS有望用作传统抗生素，具有替代肉鸡中合成抗生素生长促进剂的潜力。
