Abstract：
The accuracy of cell division requires precise regulation of the cellular machinery governing DNA/genome duplication, ensuring its equal distribution among the daughter cells. The control of the centrosome cycle is crucial for the formation of a bipolar spindle, ensuring error-free segregation of the genome. The cell and centrosome cycles operate in close synchrony along similar principles. Both require a single duplication round in every cell cycle, and both are controlled by the activity of key protein kinases. Nevertheless, our comprehension of the precise cellular mechanisms and critical regulators synchronizing these two cycles remains poorly defined. Here, we present our hypothesis that the spatiotemporal regulation of a dynamic equilibrium of mitotic kinases activities forms a molecular clock that governs the synchronous progression of both the cell and the centrosome cycles.
摘要：
细胞分裂的准确性需要精确调节控制DNA/基因组复制的细胞机制，确保其在子细胞中的均匀分布。中心体周期的控制对于双极主轴的形成至关重要，确保基因组的无差错分离。细胞和中心体周期沿着类似的原理紧密同步地操作。两者都需要在每个细胞周期中重复一轮，两者都受关键蛋白激酶的活性控制。然而，我们对同步这两个周期的精确细胞机制和关键调节因子的理解仍然不明确。这里,我们提出了我们的假设，即有丝分裂激酶活性动态平衡的时空调节形成了一个控制细胞和中心体周期同步进程的分子时钟。
