PDF(Pubmed)
Abstract：
OBJECTIVE: Pancreatic steatosis (PS) is a pathology associated with metabolic syndrome (MS), endocrin and exocrine disfunctions of the pancreas, and fatty liver. The data on the frequency of PS are very limited. We aimed to evaluate the frequency of PS detected by transabdominal ultrasonography (TAU) in gastroenterology clinics located in different geographical regions of Turkey and the factors associated with it.
METHODS: Volunteers were evaluated by TAU for PS and hepatosteatosis (HS), and its degree. Pancreatic stiffness was evaluated by ultrasonographic shear wave elastography (SWE). All demographic, physical, and biochemical parametres were measured.
RESULTS: A total of 1700 volunteers from 14 centers throughout Turkey were included in the study. Mean age was 48.03 ± 20.86 years (56.9% female). Prevalance of PS was detected in 68.9%. In the PS group, age, body mass index (BMI), waist circumference, systolic blood pressure, fasting blood glucose (FBG), lipid levels, insulin resistance, diabetes mellitus, hypertension, MS frequency, and pancreatic SWE score were increasing, and fecal elastase level was decreasing in correlation with the degree of PS. The frequency of HS was 55.5%. Hepatosteatosis [odds ratio (OR): 9.472], increased age (OR: 1.02), and BMI (OR: 1.089) were independent risk factors for the occurrence of PS. Lean-PS rate was 11.8%. The lean-PS group was predominantly female and younger than non-lean PS. Also it has lower blood pressure, FBG, liver enzymes, lipid levels, and HS rates.
CONCLUSIONS: The frequency of PS was found 68.9% in Turkey. Its relationship was determined with age, BMI, HS, MS (and its components), pancreatic stiffness, and fecal elastase level.
METHODS: Volunteers were evaluated by TAU for PS and hepatosteatosis (HS), and its degree. Pancreatic stiffness was evaluated by ultrasonographic shear wave elastography (SWE). All demographic, physical, and biochemical parametres were measured.
RESULTS: A total of 1700 volunteers from 14 centers throughout Turkey were included in the study. Mean age was 48.03 ± 20.86 years (56.9% female). Prevalance of PS was detected in 68.9%. In the PS group, age, body mass index (BMI), waist circumference, systolic blood pressure, fasting blood glucose (FBG), lipid levels, insulin resistance, diabetes mellitus, hypertension, MS frequency, and pancreatic SWE score were increasing, and fecal elastase level was decreasing in correlation with the degree of PS. The frequency of HS was 55.5%. Hepatosteatosis [odds ratio (OR): 9.472], increased age (OR: 1.02), and BMI (OR: 1.089) were independent risk factors for the occurrence of PS. Lean-PS rate was 11.8%. The lean-PS group was predominantly female and younger than non-lean PS. Also it has lower blood pressure, FBG, liver enzymes, lipid levels, and HS rates.
CONCLUSIONS: The frequency of PS was found 68.9% in Turkey. Its relationship was determined with age, BMI, HS, MS (and its components), pancreatic stiffness, and fecal elastase level.
摘要：
目的：胰腺脂肪变性（PS）是与代谢综合征（MS）相关的病理，胰腺的内分泌素和外分泌功能障碍，和脂肪肝。关于PS频率的数据非常有限。我们旨在评估位于土耳其不同地理区域的胃肠病诊所中通过经腹超声检查（TAU）检测到的PS频率及其相关因素。
方法：通过TAU评估志愿者的PS和肝骨病（HS），和它的程度。通过超声剪切波弹性成像（SWE）评估胰腺硬度。所有人口统计，物理，并测量生化参数。
结果：来自土耳其14个中心的1700名志愿者被纳入研究。平均年龄为48.03±20.86岁(56.9%为女性)。PS的患病率为68.9%。在PS组中，年龄,体重指数（BMI），腰围,收缩压,空腹血糖（FBG），脂质水平，胰岛素抵抗，糖尿病,高血压,MS频率,胰腺SWE评分增加，粪便弹性蛋白酶水平与PS程度相关。HS发生率为55.5%。肝性脂肪变性[比值比（OR）：9.472]，年龄增加（OR：1.02），BMI(OR:1.089)是PS发生的独立危险因素。精益PS率为11.8%。瘦PS组主要是女性，比非瘦PS年轻。它也有较低的血压，FBG,肝酶，脂质水平，和HS费率。
结论：在土耳其发现PS的频率为68.9%。它的关系是由年龄决定的，BMI,HS,MS（及其组件），胰腺硬度,和粪便弹性蛋白酶水平。
方法：通过TAU评估志愿者的PS和肝骨病（HS），和它的程度。通过超声剪切波弹性成像（SWE）评估胰腺硬度。所有人口统计，物理，并测量生化参数。
结果：来自土耳其14个中心的1700名志愿者被纳入研究。平均年龄为48.03±20.86岁(56.9%为女性)。PS的患病率为68.9%。在PS组中，年龄,体重指数（BMI），腰围,收缩压,空腹血糖（FBG），脂质水平，胰岛素抵抗，糖尿病,高血压,MS频率,胰腺SWE评分增加，粪便弹性蛋白酶水平与PS程度相关。HS发生率为55.5%。肝性脂肪变性[比值比（OR）：9.472]，年龄增加（OR：1.02），BMI(OR:1.089)是PS发生的独立危险因素。精益PS率为11.8%。瘦PS组主要是女性，比非瘦PS年轻。它也有较低的血压，FBG,肝酶，脂质水平，和HS费率。
结论：在土耳其发现PS的频率为68.9%。它的关系是由年龄决定的，BMI,HS,MS（及其组件），胰腺硬度,和粪便弹性蛋白酶水平。
