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Abstract：
BACKGROUND: Cleft lip and palate are congenital craniofacial anomalies that significantly impact individuals and their families, both medically and psychosocially. The Qatari population has unique characteristics that are suggestive of a high prevalence of congenital anomalies: high consanguinity rate, large family size, advanced paternal age and high prevalence of certain genetic disorders. The lack of existing data concerning the epidemiology of cleft lip and/or palate in Qatar warrants a descriptive study addressing this topic.
METHODS: A retrospective nationwide hospital-based cross-sectional study conducted to determine the prevalence of orofacial clefts in Qatar from 2016 to 2021. Data were extracted from the corporation\'s Cerner database and electronic health records. Information concerning the cleft\'s characteristics, type, affected side, patient\'s gender, presence of associated syndromes, nationality, and maternal age were collected.
RESULTS: Out of the 147,727 live births, 148 had an orofacial cleft. The prevalence of cleft lip and/or palate was determined to be 1 per 1000 livebirths (95% CI: 0.85, 1.18). The prevalence of cleft lip was 0.18 (95% CI: 0.12, 0.27), cleft palate 0.39 (95% CI: 0.30, 0.51), and cleft lip and palate 0.43 (95% CI: 0.33, 0.55). Qataris had a prevalence of CL 0.25, CP 0.40, and CLP 0.56, compared to 0.16, 0.39, 0.39 for non-Qataris (p-value 0.186). Unilateral clefts predominated over bilateral (74.4% and 25.6%, respectively). Among the unilateral cases, 70.2% occurred on the left side. Most cases were isolated clefts, with only 10.2% having associated syndromes.
CONCLUSIONS: The prevalence of orofacial clefts in Qatar is consistent with the globally reported prevalence. Most cases were unilateral and on the left side. Associated syndromes were infrequent and more common with cleft palate alone. Intriguing patterns were revealed between Qatari nationals and non-Qatari residents, with specific subtypes of orofacial clefts showing higher prevalence among nationals.
METHODS: A retrospective nationwide hospital-based cross-sectional study conducted to determine the prevalence of orofacial clefts in Qatar from 2016 to 2021. Data were extracted from the corporation\'s Cerner database and electronic health records. Information concerning the cleft\'s characteristics, type, affected side, patient\'s gender, presence of associated syndromes, nationality, and maternal age were collected.
RESULTS: Out of the 147,727 live births, 148 had an orofacial cleft. The prevalence of cleft lip and/or palate was determined to be 1 per 1000 livebirths (95% CI: 0.85, 1.18). The prevalence of cleft lip was 0.18 (95% CI: 0.12, 0.27), cleft palate 0.39 (95% CI: 0.30, 0.51), and cleft lip and palate 0.43 (95% CI: 0.33, 0.55). Qataris had a prevalence of CL 0.25, CP 0.40, and CLP 0.56, compared to 0.16, 0.39, 0.39 for non-Qataris (p-value 0.186). Unilateral clefts predominated over bilateral (74.4% and 25.6%, respectively). Among the unilateral cases, 70.2% occurred on the left side. Most cases were isolated clefts, with only 10.2% having associated syndromes.
CONCLUSIONS: The prevalence of orofacial clefts in Qatar is consistent with the globally reported prevalence. Most cases were unilateral and on the left side. Associated syndromes were infrequent and more common with cleft palate alone. Intriguing patterns were revealed between Qatari nationals and non-Qatari residents, with specific subtypes of orofacial clefts showing higher prevalence among nationals.
摘要：
背景：唇腭裂是先天性颅面畸形，对个体及其家庭有显著影响，医学和社会心理。卡塔尔人口具有独特的特征，暗示先天性异常的高患病率：高血缘率，大家庭规模，父亲年龄高，某些遗传性疾病患病率高。卡塔尔缺乏有关唇裂和/或腭裂流行病学的现有数据，因此需要进行描述性研究。
方法：进行了一项以全国医院为基础的回顾性横断面研究，以确定2016年至2021年卡塔尔口面裂的患病率。数据是从该公司的Cerner数据库和电子健康记录中提取的。关于裂口特征的信息，type,患侧,患者的性别，相关综合征的存在，国籍,和母亲的年龄被收集。
结果：在147,727例活产中，148口面裂。唇裂和/或腭裂的患病率确定为每1000例活产中有1例(95%CI:0.85,1.18)。唇裂的患病率为0.18(95%CI:0.12,0.27),腭裂0.39（95%CI：0.30，0.51），唇腭裂0.43（95%CI：0.33，0.55）。Qataris的患病率为CL0.25，CP0.40和CLP0.56，而非Qataris的患病率为0.16、0.39、0.39（p值0.186）。单侧裂隙在双侧占主导地位(74.4%和25.6%，分别)。在单方面案件中，70.2%发生在左侧。大多数病例是孤立的裂隙，只有10.2％的人患有相关综合征。
结论：卡塔尔口面裂痕的患病率与全球报告的患病率一致。大多数病例是单方面的，在左侧。相关综合征很少见，仅left裂更常见。卡塔尔国民和非卡塔尔居民之间揭示了有趣的模式，特定亚型的口面裂痕在国民中患病率较高。
方法：进行了一项以全国医院为基础的回顾性横断面研究，以确定2016年至2021年卡塔尔口面裂的患病率。数据是从该公司的Cerner数据库和电子健康记录中提取的。关于裂口特征的信息，type,患侧,患者的性别，相关综合征的存在，国籍,和母亲的年龄被收集。
结果：在147,727例活产中，148口面裂。唇裂和/或腭裂的患病率确定为每1000例活产中有1例(95%CI:0.85,1.18)。唇裂的患病率为0.18(95%CI:0.12,0.27),腭裂0.39（95%CI：0.30，0.51），唇腭裂0.43（95%CI：0.33，0.55）。Qataris的患病率为CL0.25，CP0.40和CLP0.56，而非Qataris的患病率为0.16、0.39、0.39（p值0.186）。单侧裂隙在双侧占主导地位(74.4%和25.6%，分别)。在单方面案件中，70.2%发生在左侧。大多数病例是孤立的裂隙，只有10.2％的人患有相关综合征。
结论：卡塔尔口面裂痕的患病率与全球报告的患病率一致。大多数病例是单方面的，在左侧。相关综合征很少见，仅left裂更常见。卡塔尔国民和非卡塔尔居民之间揭示了有趣的模式，特定亚型的口面裂痕在国民中患病率较高。
