Abstract：
Human embryonic aneuploidy may represent one of the final frontiers in assisted reproductive technology, primarily secondary to oocyte aneuploidy. Mammalian oocytes possess unique characteristics predisposing them to much higher rates of aneuploidy than sperm or most somatic cells. Some of these characteristics are age-independent, whereas others result from reproductive aging and environmental toxicity. A detailed understanding of these properties may lead to novel diagnostic and therapeutic tools designed to detect and prevent oocyte and embryonic aneuploidy to overcome this ultimate barrier to success in assisted reproductive technology.
摘要：
人类胚胎非整倍体可能是辅助生殖技术（ART）的最终前沿之一。主要继发于卵母细胞非整倍体。哺乳动物卵母细胞具有独特的特性，使它们比精子或大多数体细胞具有更高的非整倍体率。其中一些特征与年龄无关，而另一些是由于生殖老化和环境毒性。对这些特性的详细了解可能会导致设计用于检测和预防卵母细胞和胚胎非整倍体的新型诊断和治疗工具。克服艺术成功的最终障碍。
