Abstract：
BACKGROUND: Frailty refers to a state of weakness that can arise due to age or illnesses, and frailty predisposes individuals to several adverse health outcomes. This has been postulated to prognosticate the outcome of various surgeries, including surgeries for primary brain tumors; however, no meta-analysis has validated this finding.
METHODS: We conducted a systematic review and meta-analysis to investigate the prognostic utility of frailty for the outcome of primary brain tumor surgery. We performed a systematic search of the PubMed, EMBASE, and SCOPUS databases for studies investigating the ability of frailty to predict the outcome of primary brain tumor surgery.
RESULTS: Meta-analysis of the information provided in the thirteen studies that made up our sample. Hospital length of stay (effect size 0.94; 95% confidence interval [CI]: 0.37, 1.51; p: 0.00), postoperative complications (effect size 10.31; 95% CI: -5.88, 26.86; p: 0.21), readmission (effect size 0.82; 95% CI: 0.23, 1.41; p: 0.01), nonroutine discharge (effect size 1.07; 95% CI: 0.48, 1.65; 0.00), postoperative mortality (effect size 1.48; 95% CI: 0.81, 2.02; p: 0.00), and overall survival (effect size 1.53; 95% CI: 0.29, 2.76; p: 0.02).
CONCLUSIONS: This study showed little correlation with postoperative mortality, readmission, nonroutine discharge, length of hospital stay, or overall survival, and fragility had less significance in these areas but showed no statistical significance in predicting postoperative complications following surgery for primary brain tumors.
METHODS: We conducted a systematic review and meta-analysis to investigate the prognostic utility of frailty for the outcome of primary brain tumor surgery. We performed a systematic search of the PubMed, EMBASE, and SCOPUS databases for studies investigating the ability of frailty to predict the outcome of primary brain tumor surgery.
RESULTS: Meta-analysis of the information provided in the thirteen studies that made up our sample. Hospital length of stay (effect size 0.94; 95% confidence interval [CI]: 0.37, 1.51; p: 0.00), postoperative complications (effect size 10.31; 95% CI: -5.88, 26.86; p: 0.21), readmission (effect size 0.82; 95% CI: 0.23, 1.41; p: 0.01), nonroutine discharge (effect size 1.07; 95% CI: 0.48, 1.65; 0.00), postoperative mortality (effect size 1.48; 95% CI: 0.81, 2.02; p: 0.00), and overall survival (effect size 1.53; 95% CI: 0.29, 2.76; p: 0.02).
CONCLUSIONS: This study showed little correlation with postoperative mortality, readmission, nonroutine discharge, length of hospital stay, or overall survival, and fragility had less significance in these areas but showed no statistical significance in predicting postoperative complications following surgery for primary brain tumors.
摘要：
背景：脆弱是指由于年龄或疾病而可能出现的虚弱状态，虚弱会使个体容易出现几种不良健康结果。这是为了预测各种手术的结果，包括原发性脑肿瘤的手术；然而，没有荟萃分析证实这一发现.
方法：我们进行了系统评价和荟萃分析，以探讨虚弱对原发性脑肿瘤手术预后的影响。我们对PubMed进行了系统的搜索，EMBASE,和SCOPUS数据库，用于研究虚弱预测原发性脑肿瘤手术结果的能力。
结果：对构成我们样本的13项研究提供的信息进行荟萃分析。住院时间（LOS）（效应大小0.94；95%置信区间[CI]：0.37，1.51；p：0.00），术后并发症（效应大小10.31；95%CI：-5.88，26.86；p：0.21），再入院(效应大小0.82；95%CI：0.23，1.41；p：0.01)，非常规出院（效应大小1.07；95%CI：0.48，1.65；0.00），术后死亡率（效应大小1.48；95%CI：0.81，2.02；p：0.00），和总生存期（效应大小1.53；95%CI：0.29，2.76；p：0.02）。
结论：这项研究显示与术后死亡率的相关性很小，重新接纳,非常规放电,住院时间,或总体生存率，和脆性在这些区域的显著性较小,但在预测原发性脑肿瘤手术后并发症方面没有统计学意义.
方法：我们进行了系统评价和荟萃分析，以探讨虚弱对原发性脑肿瘤手术预后的影响。我们对PubMed进行了系统的搜索，EMBASE,和SCOPUS数据库，用于研究虚弱预测原发性脑肿瘤手术结果的能力。
结果：对构成我们样本的13项研究提供的信息进行荟萃分析。住院时间（LOS）（效应大小0.94；95%置信区间[CI]：0.37，1.51；p：0.00），术后并发症（效应大小10.31；95%CI：-5.88，26.86；p：0.21），再入院(效应大小0.82；95%CI：0.23，1.41；p：0.01)，非常规出院（效应大小1.07；95%CI：0.48，1.65；0.00），术后死亡率（效应大小1.48；95%CI：0.81，2.02；p：0.00），和总生存期（效应大小1.53；95%CI：0.29，2.76；p：0.02）。
结论：这项研究显示与术后死亡率的相关性很小，重新接纳,非常规放电,住院时间,或总体生存率，和脆性在这些区域的显著性较小,但在预测原发性脑肿瘤手术后并发症方面没有统计学意义.
