PDF(Pubmed)
Abstract：
Increased lipid peroxidation and decreased antioxidant status can result in reduced reproductive activity and fertility in aged male broiler breeders. This study was conducted to evaluate the effects of curcumin supplements (natural or nanoparticles) on the sperm characteristics, antioxidant system, fertility, and hatchability of aged roosters (54-64 wk), and to estimate the relative bioavailability value (RBV) of nano-curcumin on the measured parameters including the hypo-osmotic swelling test (HOST), motility, viability, sperm count, volume, the concentration of testosterone, glutathione peroxidase (GPx), and superoxide dismutase (SOD), diameter of the spermatogenic tube (DST), epithelium thickness (EpiTh), spermatogonia count (SPcount), fertility, hatchability, and relative weight of testis (RW-testis). A total of 30 roosters were individually caged and randomly assigned to 5 treatments comprising control (without curcumin as the basal diet), basal diet + 15 mg/kg curcumin (CUR15), basal diet + 30 mg/kg curcumin (CUR30), basal diet + 15 mg/kg nano-curcumin (Nano15), and basal diet + 30 mg/kg nano-curcumin (Nano30) for 10 wk. The slope ratio method was used to estimate the bioavailability of nano-curcumin by regressing each response on supplemental curcumin intake. Increasing dietary curcumin (P < 0.001) elicited a linear response to all studied traits. The RBV for volume, viability, motility, HOST, RW-testis, and GPx were estimated as 135 (CI: 115-156%), 143 (CI: 114-173%), 159 (CI: 122-196%), 132 (CI: 107-157%), 195 (CI: 126-264%), 176 (CI: 103-249%), and 178% (28-328%), respectively. Our findings revealed that curcumin nanoparticles enhance the reproductive efficiency of aged breeder roosters. In addition, the curcumin nanoparticles RBV exceeded that of natural curcumin, suggesting that lower concentrations of curcumin nanoparticles could have a significant effect on reproductive characteristics.
摘要：
脂质过氧化的增加和抗氧化状态的降低会导致老年雄性肉鸡饲养者的生殖活动和生育能力降低。这项研究是为了评估姜黄素补充剂（天然或纳米颗粒）对精子特征的影响，抗氧化系统，生育力,和老化公鸡的孵化率(54-64周)，并根据包括低渗肿胀试验（HOST）在内的测量参数估算纳米姜黄素的相对生物利用度（RBV），运动性,生存能力，精子计数,volume,睾酮的浓度，谷胱甘肽过氧化物酶（GPx），和超氧化物歧化酶（SOD），生精管直径（DST），上皮厚度（EpiTh），精原细胞计数（SPcount），生育力,孵化率，和睾丸的相对重量（RW-睾丸）。共有30只公鸡单独被关在笼子里，随机分配到5种治疗，包括对照（不含姜黄素作为基础饮食），基础饮食+15毫克/千克姜黄素（CUR15），基础饮食+30毫克/千克姜黄素（CUR30），基础饮食+15毫克/千克纳米姜黄素（Nano15），和基础饮食+30毫克/千克纳米姜黄素（Nano30）10周。使用斜率比方法通过回归补充姜黄素摄入的每个反应来估计纳米姜黄素的生物利用度。增加膳食姜黄素(P<0.001)引起对所有研究性状的线性响应。卷的RBV，生存能力，运动性,主机,RW-睾丸,GPx估计为135（CI：115-156%），143（CI：114-173%），159（CI：122-196%），132（CI：107-157%），195（CI：126-264%），176（CI：103-249%），和178％（28-328％），分别。我们的发现表明，姜黄素纳米颗粒可以提高老年种鸡的繁殖效率。此外,姜黄素纳米颗粒RBV超过了天然姜黄素，表明较低浓度的姜黄素纳米颗粒可能对生殖特性有显著影响。
