Abstract：
OBJECTIVE: Chronic rhinosinusitis (CRS) is a widely prevalent condition, however its degree of severity according to sex requires further study. The literature shows that sex-based differences exist in the severity of asthma and allergic airway disease in the population. These findings point to a potential hormonal cause for this difference, but there is no study suggesting the role of sex in CRS with nasal polyps (CRSwNP). The purpose of this study was to examine the association of sex and CRSwNP severity in the United States.
METHODS: This study was conducted on data gathered from 181 participants in the NAVIGATE I and NAVIGATE II randomized control trials within the OPTINOSE database. Participants were analyzed based on sex controlling for airway-related comorbidities, including history of asthma, race, and ethnicity. SNOT-22 scores were assessed as a quality-of-life outcome measure for CRS. The association between sex and SNOT-22 scores was determined using multiple linear regression.
RESULTS: There were 81 female and 100 male participants. SNOT-22 scores were significantly higher in females. The average reported SNOT-22 score was 53.8 ± 16.5 in females and 46.8 ± 18.8 in males. On adjusted regression, the association of sex and SNOT-22 scores approached but didn\'t reach significance (β: -4.97; 95 % CI: -10.68-0.73; p = 0.09).
CONCLUSIONS: On average, females had more severe manifestations of CRSwNP in comparison to males, with the adjusted association approaching statistical significance. Further studies, potentially looking at hormones as a cause of pathogenesis, are needed to better elucidate the role of sex in CRSwNP.
METHODS: This study was conducted on data gathered from 181 participants in the NAVIGATE I and NAVIGATE II randomized control trials within the OPTINOSE database. Participants were analyzed based on sex controlling for airway-related comorbidities, including history of asthma, race, and ethnicity. SNOT-22 scores were assessed as a quality-of-life outcome measure for CRS. The association between sex and SNOT-22 scores was determined using multiple linear regression.
RESULTS: There were 81 female and 100 male participants. SNOT-22 scores were significantly higher in females. The average reported SNOT-22 score was 53.8 ± 16.5 in females and 46.8 ± 18.8 in males. On adjusted regression, the association of sex and SNOT-22 scores approached but didn\'t reach significance (β: -4.97; 95 % CI: -10.68-0.73; p = 0.09).
CONCLUSIONS: On average, females had more severe manifestations of CRSwNP in comparison to males, with the adjusted association approaching statistical significance. Further studies, potentially looking at hormones as a cause of pathogenesis, are needed to better elucidate the role of sex in CRSwNP.
摘要：
目的：慢性鼻窦炎（CRS）是一种广泛流行的疾病，然而，根据性别的严重程度需要进一步研究。文献显示，人群中哮喘和过敏性气道疾病的严重程度存在性别差异。这些发现指出了这种差异的潜在荷尔蒙原因，但是没有研究表明性别在CRS伴鼻息肉（CRSwNP）中的作用。这项研究的目的是研究美国性别与CRSwNP严重程度的关系。
方法：本研究基于OPTINOSE数据库中的NAVIGATEI和NAVIGATEII随机对照试验的181名参与者收集的数据进行。参与者根据气道相关合并症的性别控制进行分析，包括哮喘病史,种族,和种族。SNOT-22评分被评估为CRS的生活质量结果指标。使用多元线性回归确定性别与SNOT-22评分之间的关联。
结果：有81名女性和100名男性参与者。女性的SNOT-22得分明显较高。女性报告的SNOT-22平均得分为53.8±16.5，男性为46.8±18.8。在调整后的回归中，性别与SNOT-22评分的相关性接近但未达到显著性(β:-4.97;95%CI:-10.68-0.73;p=0.09)。
结论：平均而言，与男性相比，女性的CRSwNP表现更严重，调整后的关联接近统计意义。进一步研究,可能将激素视为发病机理的原因，需要更好地阐明性别在CRSwNP中的作用。
方法：本研究基于OPTINOSE数据库中的NAVIGATEI和NAVIGATEII随机对照试验的181名参与者收集的数据进行。参与者根据气道相关合并症的性别控制进行分析，包括哮喘病史,种族,和种族。SNOT-22评分被评估为CRS的生活质量结果指标。使用多元线性回归确定性别与SNOT-22评分之间的关联。
结果：有81名女性和100名男性参与者。女性的SNOT-22得分明显较高。女性报告的SNOT-22平均得分为53.8±16.5，男性为46.8±18.8。在调整后的回归中，性别与SNOT-22评分的相关性接近但未达到显著性(β:-4.97;95%CI:-10.68-0.73;p=0.09)。
结论：平均而言，与男性相比，女性的CRSwNP表现更严重，调整后的关联接近统计意义。进一步研究,可能将激素视为发病机理的原因，需要更好地阐明性别在CRSwNP中的作用。
