Abstract：
BACKGROUND: Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonsteroidal anti-inflammatory drugs and analgesics, often lead to adverse effects. Krill oil is being explored as a potential alternative, however its efficacy in managing knee symptoms remains unclear.
METHODS: MEDLINE, Embase, and Cochrane databases were searched until May 2024 for studies comparing krill oil and placebo in knee pain patients. Endpoints included knee pain, stiffness, physical function, and lipid profiles (HDL-C, LDL-C, triglycerides, and total cholesterol). A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used. A trial sequential analysis was conducted to evaluate further research implications.
RESULTS: We included five trials with 700 patients using krill oil for knee pain. Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles. However, krill oil demonstrated a significant small effect in improving knee physical function (SMD -0.24, 95% CI [-0.41; -0.08], I2 = 0%).Trial sequential analysis provided certainty that krill oil enhances knee physical function compared to placebo and indicated no improvement in knee pain, but the findings for knee stiffness need to be confirmed by further research.
CONCLUSIONS: This study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function. Based on these findings, krill oil supplementation is not yet justified for knee pain.
METHODS: MEDLINE, Embase, and Cochrane databases were searched until May 2024 for studies comparing krill oil and placebo in knee pain patients. Endpoints included knee pain, stiffness, physical function, and lipid profiles (HDL-C, LDL-C, triglycerides, and total cholesterol). A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used. A trial sequential analysis was conducted to evaluate further research implications.
RESULTS: We included five trials with 700 patients using krill oil for knee pain. Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles. However, krill oil demonstrated a significant small effect in improving knee physical function (SMD -0.24, 95% CI [-0.41; -0.08], I2 = 0%).Trial sequential analysis provided certainty that krill oil enhances knee physical function compared to placebo and indicated no improvement in knee pain, but the findings for knee stiffness need to be confirmed by further research.
CONCLUSIONS: This study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function. Based on these findings, krill oil supplementation is not yet justified for knee pain.
摘要：
背景：膝关节疼痛是全球残疾的主要原因，尤其是老年人。目前的治疗方法,包括非甾体抗炎药和镇痛药，往往导致不良影响。磷虾油正在作为一种潜在的替代品进行勘探,然而，其治疗膝关节症状的疗效尚不清楚。
方法：MEDLINE，Embase,直到2024年5月，在Cochrane数据库中搜索了磷虾油和安慰剂在膝关节疼痛患者中的比较研究。终点包括膝关节疼痛，刚度,物理功能，和血脂(HDL-C，LDL-C,甘油三酯，和总胆固醇）。使用具有标准化平均差（SMD）和95％置信区间（CI）的限制性最大似然随机效应模型。进行了试验序贯分析，以评估进一步的研究意义。
结果：我们纳入了5项试验，700名患者使用磷虾油来治疗膝关节疼痛。结果显示磷虾油和安慰剂对膝关节疼痛没有显着差异，膝部刚度,和脂质分布。然而,磷虾油在改善膝关节身体功能方面表现出显著的小作用(SMD-0.24,95%CI[-0.41;-0.08],I2=0%)。试验顺序分析提供了确定性，磷虾油与安慰剂相比可增强膝关节的身体功能，并且表明膝关节疼痛没有改善。但是膝关节僵硬的发现还需要进一步的研究来证实。
结论：这项研究发现，补充磷虾油并不能明显改善膝关节疼痛，刚度,或脂质分布，虽然它可能有助于膝盖的身体功能。基于这些发现,补充磷虾油对于膝盖疼痛尚不合理。
方法：MEDLINE，Embase,直到2024年5月，在Cochrane数据库中搜索了磷虾油和安慰剂在膝关节疼痛患者中的比较研究。终点包括膝关节疼痛，刚度,物理功能，和血脂(HDL-C，LDL-C,甘油三酯，和总胆固醇）。使用具有标准化平均差（SMD）和95％置信区间（CI）的限制性最大似然随机效应模型。进行了试验序贯分析，以评估进一步的研究意义。
结果：我们纳入了5项试验，700名患者使用磷虾油来治疗膝关节疼痛。结果显示磷虾油和安慰剂对膝关节疼痛没有显着差异，膝部刚度,和脂质分布。然而,磷虾油在改善膝关节身体功能方面表现出显著的小作用(SMD-0.24,95%CI[-0.41;-0.08],I2=0%)。试验顺序分析提供了确定性，磷虾油与安慰剂相比可增强膝关节的身体功能，并且表明膝关节疼痛没有改善。但是膝关节僵硬的发现还需要进一步的研究来证实。
结论：这项研究发现，补充磷虾油并不能明显改善膝关节疼痛，刚度,或脂质分布，虽然它可能有助于膝盖的身体功能。基于这些发现,补充磷虾油对于膝盖疼痛尚不合理。
