Abstract：
Since the start of the pandemic, considerable advancements have been made in our understanding of the effects of SARS-CoV-2 infection and the associated COVID-19 on the hepatic system. There is a broad range of clinical symptoms for COVID-19. It affects multiple systems and has a dominant lung illness depending on complications. The progression of COVID-19 in people with pre-existing chronic liver disease (CLD) has also been studied in large multinational groups. Notably, SARS-CoV-2 infection is associated with a higher risk of hepatic decompensation and death in patients with cirrhosis. In this review, the source, composition, mechanisms, transmission characteristics, clinical characteristics, therapy, and prevention of SARS-CoV-2 were clarified and discussed, as well as the evolution and variations of the virus. This review briefly discusses the causes and effects of SARS-CoV-2 infection in patients with CLD. As part of COVID-19, In addition, we assess the potential of liver biochemistry as a diagnostic tool examine the data on direct viral infection of liver cells, and investigate potential pathways driving SARS-CoV-2-related liver damage. Finally, we explore how the pandemic has had a significant impact on patient behaviors and hepatology services, which may increase the prevalence and severity of liver disease in the future. The topics encompassed in this review encompass the intricate relationships between SARS-CoV-2, liver health, and broader health management strategies, providing valuable insights for both current clinical practice and future research directions.
摘要：
自从大流行开始以来，我们对SARS-CoV-2感染和相关COVID-19对肝脏系统的影响的理解已经取得了相当大的进步。COVID-19有广泛的临床症状。它影响多个系统，并根据并发症具有主要的肺部疾病。大型跨国团体也研究了COVID-19在已有慢性肝病（CLD）患者中的进展。值得注意的是,SARS-CoV-2感染与肝硬化患者肝失代偿和死亡的高风险相关。在这次审查中,源头,composition,机制,传输特性，临床特征,治疗,并对SARS-CoV-2的预防进行了澄清和讨论，以及病毒的进化和变异。本文简要讨论CLD患者SARS-CoV-2感染的原因和影响。作为COVID-19的一部分，此外，我们评估肝脏生物化学作为诊断工具的潜力，检查肝细胞直接病毒感染的数据，并研究驱动SARS-CoV-2相关肝损伤的潜在途径。最后,我们探讨大流行如何对患者行为和肝病服务产生重大影响，这可能会增加未来肝病的患病率和严重程度。本综述涵盖的主题包括SARS-CoV-2，肝脏健康，和更广泛的健康管理策略，为当前临床实践和未来研究方向提供有价值的见解。
