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Abstract：
Many studies support the idea that long noncoding RNAs (lncRNAs) are significantly involved in the process of cardiomyocyte (CM) regeneration following a myocardial infarction (MI). This study aimed to systematically review the emerging role of lncRNAs in cardiac regeneration by promoting CM proliferation after MI. Furthermore, the review summarized potential targets and the underlying mechanisms of lncRNAs to induce heart regeneration, suggesting utilizing lncRNAs as innovative therapeutic targets for mitigating MI injuries. We searched the PubMed, Scopus, and Web of Science databases for studies on lncRNAs that play a role in heart regeneration after MI. We used search terms that included MI, lncRNAs, CM, and proliferation. Relevant English articles published until June 11, 2023, were systematically reviewed based on inclusion and exclusion criteria. A total of 361 publications were initially identified, and after applying the inclusion and exclusion criteria, nine articles were included in this systematic review. These studies investigated the role of critical lncRNAs in cardiac regeneration after MI, including five upregulated and four downregulated lncRNAs. Acting as a competitive endogenous RNA is one of the main roles of lncRNAs in regulating genes involved in CM proliferation through binding to target microRNAs. The main molecular processes that greatly increase CM proliferation are those that turn on the Hippo/YAP1, PI3K/Akt, JAK2-STAT3, and E2F1-ECRAR-ERK1/2 signaling pathways. This systematic review highlights the significant role of lncRNAs in heart regeneration after MI and their impact on CM proliferation. The findings suggest that lncRNAs could serve as potential targets for therapeutic interventions aiming to enhance cardiac function.
摘要：
许多研究支持以下观点：长链非编码RNA（lncRNA）显着参与心肌梗塞（MI）后心肌细胞（CM）再生的过程。本研究旨在系统综述lncRNAs通过促进MI后CM增殖在心脏再生中的新作用。此外，这篇综述总结了lncRNAs诱导心脏再生的潜在靶标和潜在机制，建议利用lncRNAs作为减轻MI损伤的创新治疗靶点。我们搜查了PubMed,Scopus,和WebofScience数据库用于研究在MI后心脏再生中起作用的lncRNAs。我们使用了包括MI在内的搜索词，lncRNAs,CM,和扩散。直到2023年6月11日发表的相关英文文章根据纳入和排除标准进行了系统审查。初步确定共361种出版物,在应用纳入和排除标准后，本系统综述纳入了9篇文章.这些研究调查了关键lncRNAs在MI后心脏再生中的作用，包括5个上调和4个下调的lncRNAs。作为竞争性内源性RNA是lncRNAs通过与靶microRNAs结合调节参与CM增殖的基因的主要作用之一。大大增加CM增殖的主要分子过程是那些打开Hippo/YAP1，PI3K/Akt，JAK2-STAT3和E2F1-ECRAR-ERK1/2信号通路。本系统综述强调了lncRNAs在MI后心脏再生中的重要作用及其对CM增殖的影响。研究结果表明，lncRNAs可以作为旨在增强心脏功能的治疗干预的潜在靶标。
