PDF(Pubmed)
Abstract：
Eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) are chronic inflammatory disorders of the gastrointestinal tract, with EoE predominantly provoked by food and aeroallergens, whereas IBD is driven by a broader spectrum of immunopathological and environmental triggers. This review presents a comprehensive comparison of the pathophysiological and therapeutic strategies for EoE and IBD. We examine the current understanding of their underlying mechanisms, particularly the interplay between environmental factors and genetic susceptibility. A crucial element in both diseases is the integrity of the epithelial barrier, whose disruption plays a central role in their pathogenesis. The involvement of eosinophils, mast cells, B cells, T cells, dendritic cells, macrophages, and their associated cytokines is examined, highlighting the importance of targeting cytokine signaling pathways to modulate immune-epithelial interactions. We propose that advances in computation tools will uncover the significance of G-protein coupled receptors (GPCRs) in connecting immune and epithelial cells, leading to novel therapies for EoE and IBD.
摘要：
嗜酸细胞性食管炎（EoE）和炎症性肠病（IBD）是胃肠道的慢性炎症性疾病，EoE主要由食物和空气过敏原引起，而IBD是由更广泛的免疫病理学和环境触发因素驱动的。这篇综述对EoE和IBD的病理生理和治疗策略进行了全面比较。我们研究了当前对其潜在机制的理解，特别是环境因素和遗传易感性之间的相互作用。这两种疾病的关键因素是上皮屏障的完整性，其破坏在其发病机理中起着核心作用。嗜酸性粒细胞的参与，肥大细胞,B细胞,T细胞,树突状细胞,巨噬细胞，并检查了它们相关的细胞因子，强调靶向细胞因子信号通路调节免疫-上皮相互作用的重要性。我们建议计算工具的进步将揭示G蛋白偶联受体（GPCRs）在连接免疫和上皮细胞中的重要性。导致EoE和IBD的新疗法。
