PDF(Pubmed)
Abstract：
Retinopathy of prematurity (ROP) is a vascular disorder affecting the retinas of preterm infants. This condition arises when preterm infants in incubators are exposed to high oxygen levels, leading to oxidative stress, inflammatory responses, and a downregulation of vascular endothelial growth factors, which causes the loss of retinal microvascular capillaries. Upon returning to room air, the upregulation of vascular growth factors results in abnormal vascular growth of retinal endothelial cells. Without appropriate intervention, ROP can progress to blindness. The prevalence of ROP has risen, making it a significant cause of childhood blindness. Current treatments, such as laser therapy and various pharmacologic approaches, are limited by their potential for severe adverse effects. Therefore, a deeper understanding of ROP\'s pathophysiology and the development of innovative treatments are imperative. Natural products from plants, fungi, bacteria, and marine organisms have shown promise in treating various diseases and have gained attention in ROP research due to their minimal side effects and wide-ranging beneficial properties. This review discusses the roles and mechanisms of natural products that hold potential as therapeutic agents in ROP management.
摘要：
早产儿视网膜病（ROP）是一种影响早产儿视网膜的血管疾病。当孵化器中的早产儿暴露于高氧水平时，就会出现这种情况，导致氧化应激，炎症反应，血管内皮生长因子的下调，导致视网膜微血管毛细血管的丢失。回到室内空气后，血管生长因子的上调导致视网膜内皮细胞血管生长异常。如果没有适当的干预，ROP可以进展为失明。ROP的患病率有所上升,使其成为儿童失明的重要原因。目前的治疗方法,如激光治疗和各种药理学方法，受到潜在的严重不良影响的限制。因此,更深入地了解ROP的病理生理学和创新治疗方法的发展势在必行。来自植物的天然产物，真菌,细菌,和海洋生物在治疗各种疾病方面显示出希望，并且由于其最小的副作用和广泛的有益特性，在ROP研究中获得了关注。这篇综述讨论了天然产物在ROP管理中作为治疗剂的作用和机制。
