PDF(Pubmed)
Abstract：
The use of cinnamaldehyde and Vitamin C can improve immunity and intestinal health. A two-way factorial design was employed to investigate the main and interactive effects of cinnamaldehyde and vitamin C on the growth, carcass, and intestinal health of broiler chickens. A total of 288 one-day-old female Arbor Acres broiler chicks were randomly distributed among four treatment groups, consisting of six replicate cages with 12 birds each. Four treatments were basal diet or control (CON), supplemental cinnamaldehyde (CA) 300 g/ton (g/t), vitamin C (VC) 300 g/t, and cinnamaldehyde 300 g/t, and vitamin C 300 g/t (CA + VC), respectively. The results showed that supplemental CA did not affect the growth performance or slaughter performance of broilers at 21 days (d), 42 days (d), and 1-42 days (d); however, it could improve intestinal barrier function at 42 d of age and reduce the mRNA expression of inflammatory factors in the intestine at 21 d and 42 d of age. Supplemental VC showed a trend towards increasing body weight gain (BWG) at 21 d (p = 0.094), increased breast muscle rate (at 21-d 5.33%, p < 0.05 and at 42-d 7.09%, p = 0.097), and decreased the abdominal fat (23.43%, p < 0.05) and drip loss (20.68%, p < 0.05) at 42-d. Moreover, VC improves intestinal morphology and intestinal barrier function and maintains a balanced immune response. The blend of CA and VC significantly upregulated the mRNA expression of myeloid differentiation factor 88 (MyD-88) in the intestine at 21 d of age, the mRNA expression of catalase (CAT), Occludin, Claudin-1, Mucin-2, nuclear factor-kappa B (NF-κB) and toll-like receptor 4 (TLR-4) in the intestine at 42 d of age (p < 0.01), and downregulated the mRNA expression of interleukin 10 (IL-10), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α) in the intestine at 21-d and 42-d of age, and interleukin-1 beta (IL-1β) mRNA in intestine at 42 d of age (p < 0.01). This study suggested that the combination of CA and VC had the potential to regulate intestinal health and result in better carcass character of broilers.
摘要：
使用肉桂醛和维生素C可以提高免疫力和肠道健康。采用双向因子设计研究了肉桂醛和维生素C对生长的主要和相互作用的影响。屠体,和肉鸡的肠道健康。将288只1日龄雌性ArborAcres肉鸡随机分配到4个治疗组,由六个复制的笼子组成，每个笼子有12只鸟。四种处理均为基础饮食或对照(CON)，补充肉桂醛（CA）300克/吨（克/吨），维生素C(VC)300g/t,和肉桂醛300克/吨，和维生素C300g/t（CA+VC），分别。结果表明，在第21天（d），添加CA不会影响肉鸡的生长性能或屠宰性能。42天（d），和1-42天（d）；然而，可改善42d时肠道屏障功能,降低21d和42d时肠道炎症因子mRNA表达。补充VC在21d时显示出体重增加（BWG）增加的趋势（p=0.094），胸肌率增加(21d时5.33%，p<0.05，在42天7.09%时，p=0.097),并减少腹部脂肪(23.43%，p<0.05)和滴水损失(20.68%，42-d时p<0.05)。此外，VC改善肠形态和肠屏障功能并维持平衡的免疫应答。CA和VC共混显著上调21日龄肠道髓样分化因子88(MyD-88)的mRNA表达,过氧化氢酶（CAT）的mRNA表达，Occludin,42d时肠道中的Claudin-1，粘蛋白-2，核因子-κB（NF-κB）和Toll样受体4（TLR-4）（p<0.01），并下调白细胞介素10（IL-10）的mRNA表达，白细胞介素6（IL-6），21d和42d时肠道中的肿瘤坏死因子-α（TNF-α），42d时肠道白细胞介素-1β(IL-1β)mRNA表达(p<0.01)。这项研究表明，CA和VC的组合具有调节肠道健康的潜力，并导致肉鸡的car体特性更好。
