PDF(Pubmed)
Abstract：
Diabetic cardiomyopathy (DbCM) is a common complication in individuals with type 2 diabetes mellitus (T2DM), and its exact pathogenesis is still debated. It was hypothesized that chronic hyperglycemia and insulin resistance activate critical cellular pathways that are responsible for numerous functional and anatomical perturbations in the heart. Interstitial inflammation, oxidative stress, myocardial apoptosis, mitochondria dysfunction, defective cardiac metabolism, cardiac remodeling, hypertrophy and fibrosis with consequent impaired contractility are the most common mechanisms implicated. Epigenetic changes also have an emerging role in the regulation of these crucial pathways. The aim of this review was to highlight the increasing knowledge on the molecular mechanisms of DbCM and the new therapies targeting specific pathways.
摘要：
糖尿病心肌病（DbCM）是2型糖尿病（T2DM）患者的常见并发症，其确切的发病机制仍有争议。假设慢性高血糖症和胰岛素抵抗激活了关键的细胞途径，这些途径负责心脏中的许多功能和解剖扰动。间质性炎症,氧化应激，心肌细胞凋亡，线粒体功能障碍，心脏代谢缺陷,心脏重塑,肥大和纤维化以及随之而来的收缩力受损是最常见的机制。表观遗传变化在这些关键途径的调节中也具有新兴作用。这篇综述的目的是强调对DbCM分子机制和靶向特定途径的新疗法的日益深入的了解。
