PDF(Pubmed)
Abstract：
BACKGROUND: Primary hyperparathyroidism is a common endocrine disorder characterised by excessive parathormone secretion that results in hypercalcemia, primarily caused by parathyroid adenoma. Accurate localisation of hyperfunctioning tissue is essential for curative surgical treatment. Although conventional imaging modalities like ultrasonography and 99mTc-MIBI scintigraphy (SPECT) along with 18F-fluorocholine PET/CT are commonly employed, there are cases with false-negative imaging results.
METHODS: This case report presents a patient with primary hyperparathyroidism and a parathyroid adenoma detected solely through 68Ga-PSMA-11 PET/CT, typically used for prostate cancer diagnosis. The lesion observed in the PET/CT was confirmed as a parathyroid adenoma through laboratory evaluation, while other imaging techniques failed to detect it.
CONCLUSIONS: This finding suggests that the PSMA ligands\' particular affinity for neovascularisation in focal changes may facilitate the visualisation of parathyroid adenomas. The utilisation of 68Ga-PSMA-11 PET/CT in primary hyperparathyroidism could potentially improve the preoperative localization of parathyroid adenomas when conventional imaging methods are inconclusive.
METHODS: This case report presents a patient with primary hyperparathyroidism and a parathyroid adenoma detected solely through 68Ga-PSMA-11 PET/CT, typically used for prostate cancer diagnosis. The lesion observed in the PET/CT was confirmed as a parathyroid adenoma through laboratory evaluation, while other imaging techniques failed to detect it.
CONCLUSIONS: This finding suggests that the PSMA ligands\' particular affinity for neovascularisation in focal changes may facilitate the visualisation of parathyroid adenomas. The utilisation of 68Ga-PSMA-11 PET/CT in primary hyperparathyroidism could potentially improve the preoperative localization of parathyroid adenomas when conventional imaging methods are inconclusive.
摘要：
背景：原发性甲状旁腺功能亢进是一种常见的内分泌疾病，其特征是甲状旁腺激素分泌过多，导致高钙血症，主要由甲状旁腺腺瘤引起。功能亢进组织的准确定位对于治愈性手术治疗至关重要。尽管常规成像方式如超声和99mTc-MIBI闪烁显像（SPECT）以及18F-氟胆碱PET/CT通常使用，有影像学检查结果假阴性的病例。
方法：本病例报告显示1例仅通过68Ga-PSMA-11PET/CT检测的原发性甲状旁腺功能亢进症和甲状旁腺腺瘤，通常用于前列腺癌的诊断。通过实验室评估，PET/CT中观察到的病变被证实为甲状旁腺腺瘤。而其他成像技术未能检测到它。
结论：这一发现表明，PSMA配体对局灶性变化中新生血管形成的特殊亲和力可能有助于甲状旁腺腺瘤的可视化。当常规成像方法不确定时，在原发性甲状旁腺功能亢进症中使用68Ga-PSMA-11PET/CT可能会改善甲状旁腺腺瘤的术前定位。
方法：本病例报告显示1例仅通过68Ga-PSMA-11PET/CT检测的原发性甲状旁腺功能亢进症和甲状旁腺腺瘤，通常用于前列腺癌的诊断。通过实验室评估，PET/CT中观察到的病变被证实为甲状旁腺腺瘤。而其他成像技术未能检测到它。
结论：这一发现表明，PSMA配体对局灶性变化中新生血管形成的特殊亲和力可能有助于甲状旁腺腺瘤的可视化。当常规成像方法不确定时，在原发性甲状旁腺功能亢进症中使用68Ga-PSMA-11PET/CT可能会改善甲状旁腺腺瘤的术前定位。
