PDF(Pubmed)
Abstract：
Rhinosinusitis in granulomatosis with polyangiitis (GPA) is categorised as a secondary, diffuse and inflammatory chronic rhinosinusitis (CRS). It is one of the conditions that impacts the nasal microbiota. This study aimed to compare the nasal microbiomes of patients with GPA, CRS and NSP. A total of 31 patients were included in the study (18 GPA, 6 CRS and 7 nasal septum perforation (NSP)). In all patients, SNOT 22, a nasal endoscopy (Lund-Kennedy scale) and a brush swab were performed. The metagenomic analysis was carried out based on the hypervariable V3-V4 region of the 16S rRNA gene. At the genus level, statistically significant differences were observed in two comparisons: the GPA/NSP and the GPA/CRS groups. In the GPA/NSP group, the differences were related to four genera (Actinomyces, Streptococcus, Methylobacterium-Methylorubrum, Paracoccus), while in the GPA/CRS group, they were related to six (Kocuria, Rothia, Cutibacterium, Streptococcus, Methylobacterium-Methylorubrum, Tepidimonas). Patients with GPA had lower diversity compared to CRS and NSP patients. There were no statistically significant differences found for the Staphylococcus family and Staphylococcus aureus between the three groups.
摘要：
肉芽肿性多血管炎（GPA）的鼻窦炎被归类为继发性，弥漫性和炎症性慢性鼻-鼻窦炎（CRS）。它是影响鼻腔微生物群的条件之一。本研究旨在比较GPA患者的鼻腔微生物群，CRS和NSP。共有31名患者被纳入研究(18GPA，6个CRS和7个鼻中隔穿孔(NSP))。在所有患者中，进行了SNOT22，鼻内窥镜检查（Lund-Kennedy量表）和刷拭子。基于16SrRNA基因的高变区V3-V4区进行宏基因组分析。在属一级，在GPA/NSP和GPA/CRS两个比较中观察到统计学上的显著差异.在GPA/NSP组中，差异与四个属有关(放线菌，链球菌,甲基细菌-甲基细菌，Paracocus),而在GPA/CRS组中，他们与六个人(Kocuria，Rothia,Cutubacterium,链球菌,甲基细菌-甲基细菌，Tepidimonas）。与CRS和NSP患者相比，GPA患者的多样性较低。三组之间的葡萄球菌家族和金黄色葡萄球菌没有统计学上的显着差异。
