PDF(Pubmed)
Abstract：
BACKGROUND: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) has been suggested as a useful imaging method for diagnosing cyst infections in patients with autosomal dominant polycystic kidney disease (ADPKD). The aim of this article is to provide evidence-based data in this setting.
METHODS: A systematic literature review (exploring several bibliographic databases) and a bivariate meta-analysis were carried out to calculate the pooled diagnostic performance of [18F]FDG PET/CT in diagnosing probable cyst infection in ADPKD.
RESULTS: Ten studies (282 PET/CT scans and 249 patients) were included in the analysis. The pooled sensitivity and specificity of [18F]FDG PET/CT in this setting were 84.6% (95% confidence interval: 75.4-90.7) and 94.9% (95% confidence interval: 72.6-99.2), respectively, without statistical heterogeneity or significant publication bias. [18F]FDG PET/CT significantly changed patient management in more than half of ADPKD patients with suspected cyst infection.
CONCLUSIONS: [18F]FDG PET/CT has high performance in diagnosing probable cyst infections in ADPKD patients with an impact on management in the majority of patients. Although more studies are warranted, the provided evidence-based data are an important step towards the integration of [18F]FDG PET/CT in clinical and diagnostic guidelines on probable cyst infection in ADPKD patients.
METHODS: A systematic literature review (exploring several bibliographic databases) and a bivariate meta-analysis were carried out to calculate the pooled diagnostic performance of [18F]FDG PET/CT in diagnosing probable cyst infection in ADPKD.
RESULTS: Ten studies (282 PET/CT scans and 249 patients) were included in the analysis. The pooled sensitivity and specificity of [18F]FDG PET/CT in this setting were 84.6% (95% confidence interval: 75.4-90.7) and 94.9% (95% confidence interval: 72.6-99.2), respectively, without statistical heterogeneity or significant publication bias. [18F]FDG PET/CT significantly changed patient management in more than half of ADPKD patients with suspected cyst infection.
CONCLUSIONS: [18F]FDG PET/CT has high performance in diagnosing probable cyst infections in ADPKD patients with an impact on management in the majority of patients. Although more studies are warranted, the provided evidence-based data are an important step towards the integration of [18F]FDG PET/CT in clinical and diagnostic guidelines on probable cyst infection in ADPKD patients.
摘要：
背景：氟-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（[18F]FDGPET/CT）已被认为是诊断常染色体显性多囊肾病（ADPKD）患者囊肿感染的有用成像方法。本文的目的是在这种情况下提供基于证据的数据。
方法：进行了系统的文献综述（探索几个书目数据库）和双变量荟萃分析，以计算[18F]FDGPET/CT在诊断ADPKD可能的囊肿感染中的合并诊断性能。
结果：10项研究（282例PET/CT扫描和249例患者）纳入分析。在这种情况下，[18F]FDGPET/CT的合并敏感性和特异性分别为84.6％（95％置信区间：75.4-90.7）和94.9％（95％置信区间：72.6-99.2），分别,没有统计异质性或显著发表偏倚。[18F]FDGPET/CT显着改变了超过一半怀疑囊肿感染的ADPKD患者的患者管理。
结论：[18F]FDGPET/CT在诊断ADPKD患者可能的囊肿感染方面具有很高的表现，对大多数患者的治疗有影响。尽管有必要进行更多的研究，提供的循证数据是将[18F]FDGPET/CT纳入ADPKD患者可能囊肿感染的临床和诊断指南的重要一步.
方法：进行了系统的文献综述（探索几个书目数据库）和双变量荟萃分析，以计算[18F]FDGPET/CT在诊断ADPKD可能的囊肿感染中的合并诊断性能。
结果：10项研究（282例PET/CT扫描和249例患者）纳入分析。在这种情况下，[18F]FDGPET/CT的合并敏感性和特异性分别为84.6％（95％置信区间：75.4-90.7）和94.9％（95％置信区间：72.6-99.2），分别,没有统计异质性或显著发表偏倚。[18F]FDGPET/CT显着改变了超过一半怀疑囊肿感染的ADPKD患者的患者管理。
结论：[18F]FDGPET/CT在诊断ADPKD患者可能的囊肿感染方面具有很高的表现，对大多数患者的治疗有影响。尽管有必要进行更多的研究，提供的循证数据是将[18F]FDGPET/CT纳入ADPKD患者可能囊肿感染的临床和诊断指南的重要一步.
