PDF(Pubmed)
Abstract：
Male infertility represents a significant public health concern. There is a negative impact of inflammatory bowel diseases (IBDs) on the male reproductive system. The aim of this study was to investigate whether oat beta-glucan (OBG) with different molar mass can modulate parameters of antioxidant defense and inflammatory response in the testes of adult Sprague-Dawley rats with TNBS-induced colitis and whether the OBG intervention can modulate the inflammatory response in association with the RAS system. Results: higher testicular superoxide dismutase (SOD), glutathione reductase (GR) activities and glutathione (GSH) concentration, and lower testosterone (T) level and glutathione peroxidase (GPx) activity, were observed in rats with colitis than in healthy control ones. TNBS-induced colitis resulted in decreased the angiotensin 1-7 (ANG 1-7) level in the testes of rats fed with low-molar mass OBG compared to control animals. Conclusions: although colitis induced moderate pro-oxidant changes in the gonads, it seems plausible that dietary intervention with different fractions of oat beta-glucans mass may support the maintenance of reproductive homeostasis via the stimulation of the local antioxidant defense system.
摘要：
男性不育是一个重大的公共卫生问题。炎症性肠病（IBDs）对男性生殖系统有负面影响。本研究的目的是研究不同摩尔质量的燕麦β-葡聚糖（OBG）是否可以调节TNBS诱导的结肠炎成年Sprague-Dawley大鼠睾丸的抗氧化防御和炎症反应参数，以及OBG干预是否可以调节与RAS系统相关的炎症反应。结果：睾丸超氧化物歧化酶（SOD）较高，谷胱甘肽还原酶（GR）活性和谷胱甘肽（GSH）浓度，和较低的睾酮（T）水平和谷胱甘肽过氧化物酶（GPx）活性，与健康对照组相比，在结肠炎大鼠中观察到。与对照动物相比，TNBS诱导的结肠炎导致饲喂低摩尔质量OBG的大鼠睾丸中血管紧张素1-7（ANG1-7）水平降低。结论：虽然结肠炎引起了性腺的中度促氧化剂变化，似乎合理的是,对燕麦β-葡聚糖质量的不同部分进行饮食干预可能通过刺激局部抗氧化防御系统来支持生殖稳态的维持.
