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Abstract：
Methylsulfinyl hexyl isothiocyanate (6-MSITC) isolated from Eutrema japonicum is a promising candidate for the treatment of breast cancer, colorectal and stomach cancer, metabolic syndrome, heart diseases, diabetes, and obesity due to its anti-inflammatory and antioxidant properties. Also, its neuroprotective properties, improving cognitive function and protecting dopaminergic neurons, make it an excellent candidate for treating neurodegenerative diseases like dementia, Alzheimer\'s, and Parkinson\'s disease. 6-MSITC acts on many signaling pathways, such as PPAR, AMPK, PI3K/AKT/mTOR, Nrf2/Keap1-ARE, ERK1/2-ELK1/CHOP/DR5, and MAPK. However, despite the very promising results of in vitro and in vivo animal studies and a few human studies, the molecule has not yet been thoroughly tested in the human population. Nonetheless, wasabi should be classified as a \"superfood\" for the primary and secondary prevention of human diseases. This article reviews the current state-of-the-art research on 6-MSITC and its potential clinical uses, discussing in detail the signaling pathways activated by the molecule and their interactions.
摘要：
从Eutremajaponicum中分离出的异硫氰酸甲基亚磺基己酯（6-MSITC）是治疗乳腺癌的有希望的候选药物，结直肠癌和胃癌,代谢综合征,心脏病,糖尿病,和肥胖，由于其抗炎和抗氧化特性。此外，它的神经保护特性，改善认知功能和保护多巴胺能神经元，使其成为治疗神经退行性疾病如痴呆症的优秀候选药物，老年痴呆症,和帕金森病。6-MSITC作用于许多信号通路，如PPAR，AMPK,PI3K/AKT/mTOR,Nrf2/Keap1-ARE,ERK1/2-ELK1/CHOP/DR5和MAPK。然而,尽管体外和体内动物研究以及一些人体研究取得了非常有希望的结果，该分子尚未在人群中进行彻底测试。尽管如此，芥末应被归类为人类疾病一级和二级预防的“超级食品”。本文回顾了当前关于6-MSITC的最新研究及其潜在的临床应用，详细讨论了该分子激活的信号通路及其相互作用。
