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Abstract：
The aim of this study was to assess the relationship of different chronic diseases with immunonutritional markers in the senior population.
METHODS: this study included 1190 hospitalized geriatric patients. The criteria to participate were ability to communicate, given consent and C-reactive protein (CRP) lower than 6 mg/dL.
RESULTS: the mean age of the study population was 81.7 ± 7.6 years. NLR (neutrophil-to-lymphocyte ratio), LMR (lymphocyte-to-monocyte ratio), MWR (monocyte-to-white blood cell ratio), SII (systemic immune-inflammation index), PNI (prognostic nutritional index) and CAR (C-reactive protein-to-albumin ratio) were related to age. NLR and MWR were higher, while LMR, PLR (platelet-to-lymphocyte ratio and SII were lower in men. All markers were related to BMI. NLR, LMR, LCR (lymphocyte-to-CRP ratio), MWR, PNI and CAR were related to several concomitant chronic diseases. In multivariate analyses, age and BMI were selected as independent predictors of all studied immunonutritional markers. Atrial fibrillation, diabetes mellitus and dementia appear most often in the models. PNI presented the most consistent statistical association with age, BMI and concomitant chronic diseases.
CONCLUSIONS: this study reveals the pivotal role of aging and BMI in inflammatory marker levels and the association of immunonutritional markers with different chronic diseases. Atrial fibrillation seems to have the most dominant connection to the immunonutritional markers.
METHODS: this study included 1190 hospitalized geriatric patients. The criteria to participate were ability to communicate, given consent and C-reactive protein (CRP) lower than 6 mg/dL.
RESULTS: the mean age of the study population was 81.7 ± 7.6 years. NLR (neutrophil-to-lymphocyte ratio), LMR (lymphocyte-to-monocyte ratio), MWR (monocyte-to-white blood cell ratio), SII (systemic immune-inflammation index), PNI (prognostic nutritional index) and CAR (C-reactive protein-to-albumin ratio) were related to age. NLR and MWR were higher, while LMR, PLR (platelet-to-lymphocyte ratio and SII were lower in men. All markers were related to BMI. NLR, LMR, LCR (lymphocyte-to-CRP ratio), MWR, PNI and CAR were related to several concomitant chronic diseases. In multivariate analyses, age and BMI were selected as independent predictors of all studied immunonutritional markers. Atrial fibrillation, diabetes mellitus and dementia appear most often in the models. PNI presented the most consistent statistical association with age, BMI and concomitant chronic diseases.
CONCLUSIONS: this study reveals the pivotal role of aging and BMI in inflammatory marker levels and the association of immunonutritional markers with different chronic diseases. Atrial fibrillation seems to have the most dominant connection to the immunonutritional markers.
摘要：
这项研究的目的是评估老年人群中不同慢性疾病与免疫营养素标志物的关系。
方法：本研究纳入了1190例住院老年患者。参与的标准是沟通能力，同意和C反应蛋白（CRP）低于6mg/dL。
结果：研究人群的平均年龄为81.7±7.6岁。NLR（中性粒细胞与淋巴细胞之比），LMR（淋巴细胞与单核细胞的比率），MWR（单核细胞与白细胞之比），SII（全身免疫炎症指数），PNI（预后营养指数）和CAR（C反应蛋白与白蛋白之比）与年龄有关。NLR和MWR较高，而LMR,PLR（男性血小板与淋巴细胞比率和SII较低。所有指标均与BMI相关。NLR,LMR,LCR（淋巴细胞与CRP比值），MWR,PNI和CAR与几种伴随的慢性疾病有关。在多变量分析中，选择年龄和BMI作为所有研究的免疫营养标志物的独立预测因子.心房颤动,糖尿病和痴呆在模型中最常见。PNI与年龄的统计关联最一致，BMI和伴随的慢性疾病。
结论：这项研究揭示了衰老和BMI在炎症标志物水平中的关键作用以及免疫营养标志物与不同慢性疾病的关联。心房颤动似乎与免疫营养标志物具有最主要的联系。
方法：本研究纳入了1190例住院老年患者。参与的标准是沟通能力，同意和C反应蛋白（CRP）低于6mg/dL。
结果：研究人群的平均年龄为81.7±7.6岁。NLR（中性粒细胞与淋巴细胞之比），LMR（淋巴细胞与单核细胞的比率），MWR（单核细胞与白细胞之比），SII（全身免疫炎症指数），PNI（预后营养指数）和CAR（C反应蛋白与白蛋白之比）与年龄有关。NLR和MWR较高，而LMR,PLR（男性血小板与淋巴细胞比率和SII较低。所有指标均与BMI相关。NLR,LMR,LCR（淋巴细胞与CRP比值），MWR,PNI和CAR与几种伴随的慢性疾病有关。在多变量分析中，选择年龄和BMI作为所有研究的免疫营养标志物的独立预测因子.心房颤动,糖尿病和痴呆在模型中最常见。PNI与年龄的统计关联最一致，BMI和伴随的慢性疾病。
结论：这项研究揭示了衰老和BMI在炎症标志物水平中的关键作用以及免疫营养标志物与不同慢性疾病的关联。心房颤动似乎与免疫营养标志物具有最主要的联系。
