Recent Progress in Photothermal, Photodynamic and Sonodynamic Cancer Therapy: Through the cGAS-STING Pathway to Efficacy-Enhancing Strategies.

光热的最新进展 ，光动力和声动力癌症治疗 ： 通过 cGAS - STING 途径提高疗效策略。

• 影响指数: 4.927
• 发表时间: 2024 Aug 5
• 来源期刊: Molecules
• DOI: 10.3390/molecules29153704
• PMID: 39125107
• 文章类型: Journal Article
• 中科院分区: Q3
• 作者列表: Fang K,Zhang H,Kong Q,Ma Y,Xiong T,Qin T,Li S,Zhu X

关键词: cGAS-STING; cancer therapy; immunotherapy; photodynamic therapy; photothermal therapy; sonodynamic therapy; synergistic therapy

Mesh: Humans; Neoplasms / therapy drug therapy metabolism; Nucleotidyltransferases / metabolism; Membrane Proteins / metabolism; Photochemotherapy / methods; Signal Transduction / drug effects; Animals; Ultrasonic Therapy / methods; Photosensitizing Agents / pharmacology therapeutic use chemistry

Abstract

Photothermal, photodynamic and sonodynamic cancer therapies offer opportunities for precise tumor ablation and reduce side effects. The cyclic guanylate adenylate synthase-stimulator of interferon genes (cGAS-STING) pathway has been considered a potential target to stimulate the immune system in patients and achieve a sustained immune response. Combining photothermal, photodynamic and sonodynamic therapies with cGAS-STING agonists represents a newly developed cancer treatment demonstrating noticeable innovation in its impact on the immune system. Recent reviews have concentrated on diverse materials and their function in cancer therapy. In this review, we focus on the molecular mechanism of photothermal, photodynamic and sonodynamic cancer therapies and the connected role of cGAS-STING agonists in treating cancer.

摘要

光热,光动力和声动力癌症治疗提供了精确的肿瘤消融和减少副作用的机会。干扰素基因的环状鸟苷酸腺苷酸合成酶刺激物（cGAS-STING）途径被认为是刺激患者免疫系统并实现持续免疫应答的潜在靶标。结合光热，使用cGAS-STING激动剂的光动力和声动力疗法代表了一种新开发的癌症治疗方法，在其对免疫系统的影响方面表现出明显的创新。最近的综述集中在各种材料及其在癌症治疗中的功能上。在这次审查中,我们专注于光热的分子机制，光动力和声动力癌症治疗以及cGAS-STING激动剂在治疗癌症中的相关作用。