PDF(Pubmed)
Abstract：
Molecular imprinting has emerged as an important and practical technology to create economical and stable synthetic mimics of antibodies and enzymes. It has already found a variety of important applications, such as affinity separation, chemical/biological sensing, disease diagnostics, proteomics, bioimaging, controlled drug release, and catalysis. In the past decade, significant breakthroughs have been made in non-covalently imprinted polymers, from their synthesis through to their applications. In terms of synthesis, quite a few versatile and facile imprinting approaches for preparing MIPs have been invented, which have effectively solved some key issues in molecular imprinting. Additionally, important applications in several areas, such as sensors, proteomics and bioimaging, have been well demonstrated. In this review, we critically and comprehensively survey key recent advances made in the preparation of non-covalently imprinted polymers and their important applications. We focus on the state-of-art of this technology from three different perspectives: fundamentals, synthetic strategies, and applications. We first provide a fundamental basis for molecular imprinting technologies that have been developed, which is extremely helpful for establishing a sound understanding of the challenges in molecular imprinting. Then, we discuss in particular the major breakthroughs within the last ten years (2014-2024), with emphasis on new imprinting approaches, what strengths the breakthroughs can provide, and which new applications the properties of the prepared non-covalently imprinted polymers are fit for.
摘要：
分子印迹已成为产生抗体和酶的经济且稳定的合成模拟物的重要且实用的技术。它已经发现了各种重要的应用，如亲和分离，化学/生物传感，疾病诊断,蛋白质组学，生物成像,控制药物释放，和催化。在过去的十年里,非共价印迹聚合物取得了重大突破，从它们的合成到它们的应用。在合成方面,已经发明了许多用于制备MIP的通用和容易的压印方法，有效地解决了分子印迹中的一些关键问题。此外,在几个领域的重要应用，如传感器，蛋白质组学和生物成像，已经很好地证明了。在这次审查中,我们批判性和全面地调查了在制备非共价印迹聚合物及其重要应用方面取得的最新进展。我们从三个不同的角度关注这项技术的最新技术：基础，综合战略，和应用。我们首先为已经开发的分子印迹技术提供一个基本的基础，这对于建立对分子印迹挑战的良好理解非常有帮助。然后，我们特别讨论了过去十年(2014-2024年)内的重大突破，强调新的印记方法，突破可以提供什么优势，以及所制备的非共价印迹聚合物的性能适合哪些新应用。
