PDF(Pubmed)
Abstract：
The occurrence of second primary malignancies is becoming increasingly important among cancer survivors. Melanoma, an aggressive neoplasm originating from the melanocytes, is responsible for most skin cancer-related deaths. This review aims to explore the risk of melanoma occurrence as a second primary cancer after the most common subtypes of hematologic neoplasia, a malignant disease originating from myeloid or lymphocytic cell lineages. Chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) are among the most associated subtypes with melanoma development. We also discuss the underlying hypotheses that may explain the associations between these malignancies and the impact of melanoma on survival. The review emphasizes the importance of increasing awareness of melanoma risk in hematologic cancer survivors, as it can lead to prompt recognition, improved skin surveillance, and better survival outcomes.
摘要：
第二原发性恶性肿瘤的发生在癌症幸存者中变得越来越重要。黑色素瘤,一种起源于黑素细胞的侵袭性肿瘤，是大多数皮肤癌相关死亡的原因。这篇综述旨在探讨黑色素瘤作为最常见的血液肿瘤亚型之后的第二原发癌的发生风险。起源于髓系或淋巴细胞谱系的恶性疾病。慢性淋巴细胞白血病（CLL）和非霍奇金淋巴瘤（NHL）是与黑色素瘤发展最相关的亚型之一。我们还讨论了可能解释这些恶性肿瘤与黑色素瘤对生存影响之间关联的潜在假设。该综述强调了提高血液肿瘤幸存者对黑色素瘤风险认识的重要性。因为它可以导致迅速的识别，改善皮肤监测，和更好的生存结果。
