PDF(Pubmed)
Abstract：
Background: Obesity and overweight are also becoming more prevalent among women of childbearing age and pregnant women. In maternal obesity, the activation of metabolic, inflammatory, and oxidative stress pathways is proven, which appears to be a key step in the pathological changes observed in placental and uterine function. Several recent studies have evidenced that aquaporins (AQPs) are critical players in adipose tissue biology and are involved in the onset of obesity. Methods: Our studies aimed to investigate the changes in placental volume and vascularization and measure the AQP5 expression and total antioxidant capacity (TAC) in the placenta and uterus tissues in obese and typical-weight mothers. We also aim to measure the AQP5 plasma concentration. Results: We found AQP5 dominance in the uterus and plasma at 34 weeks of normal pregnancy. The placental volume increased and the vascularization decreased in obese mothers compared to the control. The AQP5 expression increased in the uterus of the obese group and did not change in the placenta. The TAC decreased in the plasma of overweight mothers. Conclusions: We hypothesize that increased AQP5 expression prolongs the length of pregnancy and inhibits the onset of contractions. Based on our findings, we can develop diagnostic tests and provide new targets for tocolytic drug development.
摘要：
背景：肥胖和超重在育龄妇女和孕妇中也越来越普遍。在产妇肥胖中，代谢的激活，炎症，氧化应激途径得到证实，这似乎是在胎盘和子宫功能观察到的病理变化的关键步骤。最近的几项研究表明，水通道蛋白（AQP）是脂肪组织生物学的关键参与者，并参与肥胖的发作。方法：我们的研究旨在研究肥胖和典型体重母亲胎盘体积和血管形成的变化，并测量胎盘和子宫组织中AQP5的表达和总抗氧化能力（TAC）。我们还旨在测量AQP5血浆浓度。结果：在正常妊娠34周时，我们发现子宫和血浆中AQP5占优势。与对照组相比，肥胖母亲的胎盘体积增加，血管形成减少。肥胖组子宫AQP5表达增加，胎盘无变化。超重母亲血浆中的TAC降低。结论：我们假设AQP5表达的增加延长了妊娠时间并抑制了宫缩的发生。根据我们的发现,我们可以开发诊断测试，并为保胎药物开发提供新的靶点。
