PDF(Pubmed)
Abstract：
Background: Population-based cancer registries are the best source of information to measure cancer burden. However, little is done to use this information for individual cancer risk assessment. In this study, we aimed at identifying women at high risk of breast and ovarian cancer using data on family history of cancer from the Israel national cancer registry. Methods: We used the family history assessment tool (FHAT) to score all females, 26 to 45 years of age, in a 2.6-million-member health provider in Israel (Maccabi Healthcare Services). Data on breast, ovarian, prostate, and pancreatic cancer history among the participants and their parents (identified using the national census) were retrieved from the national cancer registry. These data were used to calculate individual FHAT scores. Results: A total of 377,931 eligible women were included in the analysis. A relevant family history of cancer was detected in 20,386 (5.4%), with FHAT scores ranging from 1 to 16. FHAT score was higher in older women and among those with a history of breast cancer. Among women aged 35-39, an FHAT score of 10 or above was associated with an OR of 15.23 (95%CI: 7.41-28.19) for breast cancer compared to women with an FHAT of 0. Conclusions: Using individual-level data from national cancer registries may assist in detecting women with a relevant family history of cancer.
摘要：
背景：基于人群的癌症登记是衡量癌症负担的最佳信息来源。然而,很少将这些信息用于个体癌症风险评估。在这项研究中,我们的目标是利用以色列国家癌症登记处的癌症家族史数据,确定乳腺癌和卵巢癌高危女性.方法：我们使用家族史评估工具（FHAT）对所有女性进行评分，26至45岁，在以色列拥有260万会员的医疗服务提供者（马卡比医疗保健服务）中。乳房数据，卵巢,前列腺,参与者及其父母的胰腺癌病史(使用国家人口普查确定)从国家癌症登记处检索.这些数据用于计算个体FHAT评分。结果：共有377,931名合格妇女被纳入分析。在20,386（5.4％）中发现了相关的癌症家族史，FHAT评分范围从1到16。老年女性和有乳腺癌病史的女性中FHAT得分较高。在35-39岁的女性中，与FHAT为0的女性相比，FHAT评分为10或以上的乳腺癌的OR为15.23（95CI：7.41-28.19）。结论：使用来自国家癌症登记处的个人水平数据可能有助于检测具有相关癌症家族史的女性。
