PDF(Pubmed)
Abstract：
Background: Alterations in the serum lipid profile have been suspected in many psychiatric disorders, such as schizophrenia and depression. However, studies on lipid status in attention-deficit/hyperactivity disorder (ADHD) are sparse and inconsistent. Methods: Using the nationwide, population-based IQVIA Disease Analyzer database, this retrospective cohort study included 5367 outpatients from general practices in Germany aged ≥18 years with a documented first diagnosis of ADHD between January 2005 and December 2021 and 26,835 propensity score-matched individuals without ADHD. Study outcomes were the first diagnosis of lipid metabolism disorders as a function of ADHD within up to 10 years of the index date. The cumulative 10-year incidence was analyzed using Kaplan-Meier curves and compared using the log-rank test. In addition, univariate Cox regression analyses were performed. Results: In the regression analysis, there was no significant association between ADHD and subsequent lipid metabolism disorders in the total population (HR: 0.94; 95% CI: 0.83-1.08), among women (HR: 1.04; 95% CI: 0.84-1.28), and among men (HR: 0.89; 95% CI: 0.74-1.06). In addition, no significant association was observed in the disease-stratified analyses. Conclusions: The findings of this study indicate that ADHD does not exert an influence on lipid metabolism. However, further investigation is warranted, particularly with respect to pharmacological interventions.
摘要：
背景：在许多精神疾病中都怀疑血脂谱的改变，比如精神分裂症和抑郁症。然而,关于注意缺陷/多动障碍(ADHD)患者血脂状况的研究很少且不一致.方法:采用全国范围内,基于人群的IQVIA疾病分析仪数据库，这项回顾性队列研究纳入了2005年1月至2021年12月期间德国全科医生共5367例门诊患者,年龄≥18岁,有记录的首次诊断为ADHD患者,以及26,835例倾向评分匹配的无ADHD患者.研究结果是在索引日期的10年内首次诊断出作为ADHD功能的脂质代谢紊乱。使用Kaplan-Meier曲线分析累积10年发病率，并使用对数秩检验进行比较。此外,进行单变量Cox回归分析.结果：在回归分析中，在总人群中，ADHD与随后的脂质代谢紊乱之间没有显着关联（HR：0.94;95％CI：0.83-1.08），女性（HR：1.04；95%CI：0.84-1.28），男性（HR：0.89；95%CI：0.74-1.06）。此外,在疾病分层分析中未观察到显著关联.结论：这项研究的结果表明，ADHD对脂质代谢没有影响。然而,需要进一步调查，特别是在药物干预方面。
