PDF(Pubmed)
Abstract：
Background/Objectives: Temporomandibular dysfunction syndrome consists of several disorders of the masticatory system, namely those of the muscles, the joint itself, as well as the dental and periodontal system. This syndrome is often characterized by pain and an inability to perform functions within the dental-maxillary apparatus, which creates a certain degree of disability in patients. Women are more susceptible to this syndrome than men and hormonal factors, particularly estrogen, are central to its etiology and physiopathology. Methods: A comprehensive literature search was conducted using PubMed/MEDLINE, Scopus, Embase, and Web of Science databases regarding articles published from January 2008 to December 2023. Two authors conducted searches in the mentioned databases based on a pre-established search strategy using agreed-upon keywords. Additionally, each review author performed the selection process of eligible studies based on established inclusion criteria. The Newcastle-Ottawa scale and Risk of Bias tool 2 were used to assess each article for its methodological quality. Results: Of the 1030 records found in the four bibliographic databases, 22 studies were included in this review. Polymorphism in the alpha estrogen receptor appears to be significantly more prevalent in women with temporomandibular dysfunction, suggesting a genetic predisposition. There is a significant role of estrogen in the physiopathology of TMD-related pain. Women with polycystic ovary syndrome (PCOS) have a significantly higher incidence of TMD, accompanied by elevated inflammatory factors and decreased progesterone levels. In premenopausal women, there is scientific relevance to the association between beta-estradiol levels and TMD development and progression. The effects of estrogen hormones on temporomandibular dysfunction remain highly debated and challenging. Conclusions: These findings emphasize the importance of considering hormonal factors, genetic predisposition, and reproductive life stages in understanding and managing temporomandibular dysfunction. Further research is needed to elucidate the specific mechanisms underlying these associations.
摘要：
背景/目的：颞下颌关节功能障碍综合征包括几种咀嚼系统疾病，即肌肉，关节本身，以及牙齿和牙周系统。这种综合征的特征通常是疼痛和无法在上颌牙器内执行功能，这会给患者造成一定程度的残疾。女性比男性和荷尔蒙因素更容易患这种综合症，特别是雌激素，是其病因和病理生理学的核心。方法：使用PubMed/MEDLINE进行全面的文献检索，Scopus,Embase,和WebofScience数据库有关2008年1月至2023年12月发表的文章。两位作者基于使用商定的关键字的预先建立的搜索策略在上述数据库中进行搜索。此外,每位综述作者根据既定的纳入标准选择符合条件的研究.使用纽卡斯尔-渥太华量表和偏见风险工具2评估每篇文章的方法学质量。结果：在四个书目数据库中发现的1030条记录中，22项研究纳入本综述。α雌激素受体的多态性似乎在颞下颌关节功能障碍的女性中更为普遍，暗示了遗传倾向.雌激素在TMD相关疼痛的病理生理学中具有重要作用。多囊卵巢综合征(PCOS)患者TMD发病率明显增高,伴有炎症因子升高和孕酮水平降低。在绝经前的女性中，β-雌二醇水平与TMD发展和进展之间存在科学相关性.雌激素对颞下颌关节功能障碍的影响仍然存在争议和挑战性。结论：这些发现强调了考虑激素因素的重要性，遗传易感性,理解和管理颞下颌功能障碍的生殖生命阶段。需要进一步的研究来阐明这些关联的具体机制。
