PDF(Pubmed)
Abstract：
BACKGROUND: Graves\' disease (GD) is an autoimmune disorder affecting the thyroid gland, leading to systemic manifestations such as hyperthyroidism, Graves\' orbitopathy, and pretibial myxedema. Contrary to previous beliefs that hyperthyroidism protects against thyroid cancer, recent studies reveal an increased incidence of thyroid malignancies in GD patients, particularly differentiated thyroid carcinomas and, in rare cases, medullary thyroid carcinoma (MTC).
METHODS: This case series presents three female GD patients diagnosed with MTC, highlighting the complexities of diagnosis and management. All patients exhibited thyroid nodules with suspicious ultrasonographic features, elevated plasma calcitonin levels, and required total thyroidectomy. Histological examination confirmed MTC.
CONCLUSIONS: These cases underscore the importance of routine calcitonin screening in GD patients with thyroid nodules to facilitate early detection and improve prognosis. Our findings suggest that while the coexistence of GD and MTC is likely incidental, vigilant monitoring and comprehensive evaluation are crucial for timely intervention.
CONCLUSIONS: This study advocates for integrating calcitonin testing into the standard diagnostic protocol for GD patients presenting with thyroid abnormalities.
METHODS: This case series presents three female GD patients diagnosed with MTC, highlighting the complexities of diagnosis and management. All patients exhibited thyroid nodules with suspicious ultrasonographic features, elevated plasma calcitonin levels, and required total thyroidectomy. Histological examination confirmed MTC.
CONCLUSIONS: These cases underscore the importance of routine calcitonin screening in GD patients with thyroid nodules to facilitate early detection and improve prognosis. Our findings suggest that while the coexistence of GD and MTC is likely incidental, vigilant monitoring and comprehensive evaluation are crucial for timely intervention.
CONCLUSIONS: This study advocates for integrating calcitonin testing into the standard diagnostic protocol for GD patients presenting with thyroid abnormalities.
摘要：
背景：Graves病（GD）是一种影响甲状腺的自身免疫性疾病，导致全身表现，如甲状腺功能亢进，Graves\'眼眶病,胫骨前粘液水肿.与以前认为甲状腺功能亢进可以预防甲状腺癌的观点相反，最近的研究表明GD患者甲状腺恶性肿瘤的发病率增加，特别是分化型甲状腺癌，在极少数情况下，甲状腺髓样癌（MTC）。
方法：本病例系列介绍了三名诊断为MTC的女性GD患者，强调诊断和管理的复杂性。所有患者均表现为甲状腺结节，具有可疑的超声特征，血浆降钙素水平升高，需要全甲状腺切除术.组织学检查证实MTC。
结论：这些病例强调了常规降钙素筛查对伴有甲状腺结节的GD患者的早期发现和改善预后的重要性。我们的研究结果表明，虽然GD和MTC的共存可能是偶然的，警惕的监测和综合评估对于及时干预至关重要。
结论：本研究主张将降钙素检测纳入甲状腺异常的GD患者的标准诊断方案。
方法：本病例系列介绍了三名诊断为MTC的女性GD患者，强调诊断和管理的复杂性。所有患者均表现为甲状腺结节，具有可疑的超声特征，血浆降钙素水平升高，需要全甲状腺切除术.组织学检查证实MTC。
结论：这些病例强调了常规降钙素筛查对伴有甲状腺结节的GD患者的早期发现和改善预后的重要性。我们的研究结果表明，虽然GD和MTC的共存可能是偶然的，警惕的监测和综合评估对于及时干预至关重要。
结论：本研究主张将降钙素检测纳入甲状腺异常的GD患者的标准诊断方案。
