PDF(Pubmed)
Abstract：
Background/Objectives: Congenital cytomegalovirus (cCMV) is the leading infectious cause of sensorineural hearing loss and neurodevelopmental disabilities, with prompt detection (<21 days of life) required to enable accurate diagnosis and anti-viral treatment where clinically appropriate. International guidelines recommend cCMV screening for infants who do not pass their Universal Newborn Hearing Screening (UNHS). This study aimed to explore parental experiences of targeted cCMV screening through the UNHS in Victoria, Australia between 2019 and 2020 (HearS-cCMV study). Methods: A qualitative study comprising 18 semi-structured interviews with parents who took saliva swabs from their infants who did not pass their UNHS. A maximum variation sampling strategy was used with data analysed using thematic analysis. Results: Four themes described 18 parents\' experiences of cCMV screening: (1) parents\' lack of CMV awareness prior to cCMV screening; (2) overall positive experience; (3) varied understanding of CMV post screening; and (4) parents were glad to screen their infant for cCMV. Enablers of targeted cCMV screening included the swab being simple and non-invasive, being easier to complete in the hospital than at home, and the screening being well delivered by the staff. Barriers included a potential increase in anxiety, especially with false positives, and the timing of cCMV screening coinciding with their infant not passing UNHS being difficult for some parents. Conclusions: Parent experiences of targeted cCMV screening were positive. Increasing public knowledge of cCMV and training staff members to complete the CMV swab would reduce the risk of false positives and associated parental anxiety. This would facilitate successful routine targeted cCMV screening.
摘要：
背景/目的：先天性巨细胞病毒（cCMV）是感音神经性听力损失和神经发育障碍的主要传染性原因，及时检测（<21天的生命），以便在临床上适当的情况下进行准确诊断和抗病毒治疗。国际指南建议对未通过通用新生儿听力筛查（UNHS）的婴儿进行cCMV筛查。本研究旨在探索通过维多利亚州UNHS进行有针对性的cCMV筛查的父母经验，2019年至2020年之间的澳大利亚（HearS-cCMV研究）。方法：一项定性研究，包括对未通过UNHS的婴儿的唾液拭子的父母进行18次半结构化访谈。使用最大变异抽样策略，并使用主题分析进行数据分析。结果：四个主题描述了18位父母的cCMV筛查经验：（1）父母在cCMV筛查前缺乏CMV意识；（2）总体积极的经验；（3）筛查后对CMV的理解不同；（4）父母很高兴为cCMV筛查婴儿。有针对性的cCMV筛查的启动者包括拭子简单且非侵入性，在医院比在家里更容易完成，工作人员很好地进行了筛查。障碍包括焦虑的潜在增加，尤其是假阳性，cCMV筛查的时间与他们的婴儿没有通过UNHS的时间相吻合，这对一些父母来说是困难的。结论：父母对cCMV进行靶向筛查的经验是积极的。增加公众对cCMV的了解并培训工作人员完成CMV拭子将降低假阳性和相关父母焦虑的风险。这将有助于成功的常规靶向cCMV筛选。
