PDF(Pubmed)
Abstract：
The breeding of high-quality beef cattle breeds is crucial for the development of animal husbandry, and whole-genome resequencing is widely applicated in the field of molecular breeding. Advantages in growth and reproductive traits exist in Pinan cattle compared with other cattle breeds, but there is limited research on its genomic mechanism. Using whole-genome resequencing, the genetic structure and genomic selection signatures in Pinan cattle were investigated in this study. Phylogenetic, cluster, and admixture analysis results indicated that Pinan cattle have a closer genetic relationship with Kholmogory cattle and China north cattle breeds. Through a selective sweep strategy, 207 and 54 candidate genes related to growth and reproduction and immunity, respectively, were identified in the Pinan cattle population. Given the crucial role of the glutamate-cysteine ligase catalytic (GCLC) gene in muscle antioxidative defense, the high frequency of allele T of the GCLC c.429 C>T locus in the Pinan cattle population might partially contribute to the advantages of Pinan cattle in growth performance. This study laid the foundation for the genetic improvement in Chinese local beef cattle and provide background for the studies on the growth and development of Pinan cattle.
摘要：
优质肉牛品种的选育对畜牧业的发展至关重要,全基因组重测序在分子育种领域有着广泛的应用。与其他牛品种相比，皮南牛在生长和繁殖性状上存在优势，但是对其基因组机制的研究有限。使用全基因组重测序，本研究调查了皮南牛的遗传结构和基因组选择特征。系统发育,群集,和混合物分析结果表明，皮南牛与Kholmogory牛和中国北方牛品种具有更紧密的亲缘关系。通过选择性扫描策略，207和54个与生长、繁殖和免疫相关的候选基因，分别,在皮南牛种群中被发现。鉴于谷氨酸-半胱氨酸连接酶催化（GCLC）基因在肌肉抗氧化防御中的关键作用，Pinan牛种群中GCLCc.429C>T基因座的等位基因T的高频率可能部分有助于Pinan牛在生长性能上的优势。本研究为中国地方肉牛的遗传改良奠定了基础，也为皮南牛的生长发育研究提供了背景。
