METHODS: We conducted a retrospective clinical study on patients with Oral Squamous Cell Carcinoma (OSCC) and Lung Squamous Cell Carcinoma (LUSCC), examining stages, comorbidities, treatments, and outcomes. We evaluated the prognostic significance of pre-surgical systemic inflammation markers and tumor microenvironment composition.
RESULTS: Associations were found between systemic inflammation markers-NLR, MLR, and PLR-and tumor microenvironment factors, such as TILs and CD8+ cell prevalence-elevated inflammation markers correlated with advanced stages. Specifically, NLR was prognostic in OSCC, whereas PLR was prognostic in LUSCC. Using a cutoff value, we divided our tumor samples into two prognostic groups. Moreover, TILs levels >15% of tumor stroma correlated with prolonged overall survival in both OSCC and LUSCC, while increased CD8+ expression was linked to extended disease-free survival in LUSCC.
CONCLUSIONS: Systemic inflammation markers and TILs can be valuable prognostic factors of survival, highlighting the immune response\'s role in OSCC and LUSCC. Despite limited clinical integration of the presented cohorts due to a lack of standardization, we concluded that analyzing tumor immune profiles may offer novel prognostic insights.
CONCLUSIONS: Future integration into cancer classification could improve risk stratification and treatment guidance.
方法:我们对口腔鳞状细胞癌(OSCC)和肺鳞癌(LUSCC)患者进行了回顾性临床研究,检查阶段,合并症,治疗,和结果。我们评估了手术前全身炎症标志物和肿瘤微环境组成的预后意义。
结果:发现全身性炎症标志物-NLR之间存在关联,MLR,以及PLR和肿瘤微环境因素,如TIL和CD8+细胞患病率升高的炎症标志物与晚期相关。具体来说,NLR在OSCC中具有预后性,而PLR在LUSCC中是预后的。使用截止值,我们将肿瘤样本分为两个预后组.此外,TIL水平>15%的肿瘤基质与OSCC和LUSCC的总生存期延长相关,而CD8+表达增加与LUSCC无病生存期延长相关。
结论:系统性炎症标志物和TILs可能是有价值的生存预后因素,强调免疫反应在OSCC和LUSCC中的作用。尽管由于缺乏标准化,所提出的队列的临床整合有限,我们得出结论,分析肿瘤免疫谱可能提供新的预后见解.
结论:未来整合到癌症分类中可以改善风险分层和治疗指导。