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Abstract：
The Controlling Nutritional Status (CONUT) score is a novel nutritional index that integrates the serum albumin level, peripheral blood lymphocyte count, and total cholesterol level. This retrospective study explores its prognostic significance in patients undergoing cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). We included 436 patients who underwent CRS-HIPEC, categorized into low (0-3) and high (4-12) CONUT score groups, and performed logistic regression analysis to predict one-year mortality and postoperative morbidity. Our findings revealed that high CONUT scores correlate with increased one-year mortality (47.1% vs. 20.3%, p < 0.001) and morbidity (39.2% vs. 18.2%, p < 0.001) compared to low CONUT scores. Multivariable regression analysis confirmed high CONUT scores as independent predictors of one-year mortality (odds ratio: 2.253, 95% CI: 1.014-5.005, p = 0.046) and postoperative morbidity (odds ratio: 2.201, 95% CI: 1.066-4.547, p = 0.033). These results underscore the CONUT score\'s effectiveness as an independent marker for evaluating risks associated with CRS-HIPEC, emphasizing its potential to improve risk stratification.
摘要：
控制营养状况（CONUT）评分是一种新的营养指数，它整合了血清白蛋白水平，外周血淋巴细胞计数,和总胆固醇水平。这项回顾性研究探讨了其在接受细胞减灭术联合腹腔热化疗（CRS-HIPEC）的患者中的预后意义。我们纳入了436例接受CRS-HIPEC的患者，分为低（0-3）和高（4-12）CONUT得分组，并进行logistic回归分析以预测1年死亡率和术后发病率。我们的研究结果表明，高CONUT得分与一年死亡率增加相关(47.1%与20.3%,p<0.001）和发病率（39.2%vs.18.2%,p<0.001)与低CONUT评分相比。多变量回归分析证实高CONUT评分是一年死亡率(比值比:2.253,95%CI:1.014-5.005,p=0.046)和术后发病率(比值比:2.201,95%CI:1.066-4.547,p=0.033)的独立预测因子。这些结果强调了CONUT评分作为评估与CRS-HIPEC相关风险的独立指标的有效性，强调其改善风险分层的潜力。
